1999: Signaling and Gene Expression in the Immune System, Vol. LXIV
Organizer: Bruce Stillman
Symposium Participants v Foreword xxi Lymphocyte Development Lymphoid Development from Stem Cells and the Common Lymphocyte ProgenitorsK. Akashi, M. Kondo, S. Cheshier, J. Shizuru, K. Gandy, J. Domen, R. Mebius, D. Traver,and I.L. Weissman 1 PU.1, a Shared Transcriptional Regulator of Lymphoid and Myeloid Cell Fates H. Singh,R.P. DeKoter, and J.C. Walsh 13 Differentiation, Dedifferentiation, and Redifferentiation of B-lineage Lymphocytes: Roles ofthe Surrogate Light Chain and the Pax5 Gene A. Rolink, S. Nutt, M. Busslinger,E. ten Boekel, T. Seidl, J. Andersson, and F. Melchers 21 Notch and the CD4 Versus CD8 Lineage Decision P. Valdez and E. Robey 27 Consequences of Notch-mediated Inhibition of the Transcription Factor E47 W. Pear, Z. Tang, S. DeRocco, D. Allman, R. Hardy, J. Pui, L. Xu, F. Karnell, J. Aster, and T. Kadesch 33 Role of Helix-Loop-Helix Proteins in Lymphocyte Development C. Murre 39 Controlling Lymphopoiesis with a Combinatorial E-protein Code R.J. Barndt and Y. Zhuang 45 The Molecular Basis of B-cell Lineage Commitment S.L. Nutt, A.G. Rolink, and M. Busslinger 51 Role of B-lymphocyte-induced Maturation Protein-1 in Terminal Differentiation of B Cells andOther Cell Lineages C. Angelin-Duclos, G. Cattoretti, D.H. Chang, K.-I. Lin, Y. Lin,J. Yu, and K. Calame 61 The Lymphochip: A Specialized cDNA Microarray for the Genomic-scale Analysis of GeneExpression in Normal and Malignant Lymphocytes A. Alizadeh, M. Eisen, R.E. Davis,C. Ma, H. Sabet, T. Tran, J.I. Powell, L. Yang, G.E. Marti, D.T. Moore, J.R. Hudson, Jr.,W.C. Chan, T. Greiner, D. Weisenburger, J.O. Armitage, I. Lossos, R. Levy, D. Botstein,P.O. Brown, and L.M. Staudt 71 Transcription Factors and the Control of Lymphocyte Development Ikaros Chromatin Remodeling Complexes in the Control of the Differentiation of theHemo-lymphoid System J. Koipally, J. Kim, B. Jones, A. Jackson, N. Avitahl,S. Winandy, M. Trevisan, A. Nichogiannopoulou, C. Kelley, and K. Georgopoulos 79 Mechanisms of Transcriptional Regulation in Lymphocyte Progenitors: Insight from anAnalysis of the Terminal Transferase Promoter P. Ernst, K. Hahm, B.S. Cobb,K.E. Brown, L.A. Trinh, A.S. McCarty, M. Merkenschlager, C.A. Klug, A.G. Fisher,and S.T. Smale 87 Mechanisms of m Enhancer Regulation in B Lymphocytes B.S. Nikolajczyk, W. Dang, and R. Sen 99 Differential Regulation of Immunoglobulin Gene Transcription via Nuclear Matrix-associatedRegions C. Webb, R.-T. Zong, D. Lin, Z. Wang, M. Kaplan, Y. Paulin, E. Smith, L. Probst,J. Bryant, A. Goldstein, R. Scheuermann, and P. Tucker 109 B-cell-specific Coactivator OCA-B: Biochemical Aspects, Role in B-Cell Development andBeyond Y. Luo and R.G. Roeder 119 Control of Lymphocyte Differentiation by the LEF-1/TCF Family of Transcription FactorsT. Reya, R. Okamura, and R. Grosschedl 133 Activation and Repression of Wingless/Wnt Target Genes by the TCF/LEF-1 Family ofTranscription Factors H.C. Korswagen and H.C. Clevers 141 The INF-b Enhancer: A Paradigm for Understanding Activation and Repression of InducibleGene Expression N. Munshi, J. Yie, M. Merika, K. Senger, S. Lomvardas, T. Agalioti, and D. Thanos 149 Recombination and Allelic Exclusion V(D)J Recombination: Links to Transposition and Double-strand Break Repair M. Gellert,J.E. Hesse, K. Hiom, M. Melek, M. Modesti, T.T. Paull, D.A. Ramsden, and D.C. van Gent 161 Nonhomologous End-joining Proteins Are Required for V(D)J Recombination, Normal Growth,and Neurogenesis J.M. Sekiguchi, Y. Gao, Y. Gu, K. Frank, Y. Sun, J. Chaudhuri, C. Zhu,H.-L. Cheng, J. Manis, D. Ferguson, L. Davidson, M.E. Greenberg, and F.W. Alt 169 Regulation of Chromatin Accessibility for V(D)J Recombination C. Hernandez-Munain,M. Taylor McMurry, and M.S. Krangel 183 What Prevents Intermolecular V(D)J Recombination? L.E. Huye, J.-O. Han, and D.B. Roth 191 Demethylation and the Establishment of k Allelic Exclusion R. Mostoslavsky, A. Kirillov,Y.-H. Ji, M. Goldmit, M. Holzmann, T. Wirth, H. Cedar, and Y. Bergman 197 RAG Expression in B Cells in Secondary Lymphoid Tissues W. Yu, H. Nagaoka, Z. Misulovin,E. Meffre, H. Suh, M. Jankovic, N. Yannoutsos, R. Casellas, E. Besmer, F. Papavasiliou,X. Qin, and M.C. Nussenzweig 207 Antibody Diversification and Selection in the Mature B-Cell Compartment M.S. Neuberger,A. Lanoue, M.R. Ehrenstein, F.D. Batista, J.E. Sale, and G.T. Williams 211 Molecular Mechanism of Immunoglobulin Class Switch Recombination K. Kinoshita,C.-G. Lee, J. Tashiro, M. Muramatsu, X.-C. Chen, K. Yoshikawa, and T. Honjo 217 Molecular Aspects of Somatic Hypermutation of Immunoglobulin Genes U. Storb, A. Peters,N. Kim, H.M. Shen, G. Bozek, N. Michael, J. Hackett, Jr., E. Klotz, J.D. Reynolds,L.A. Loeb, and T.E. Martin 227 T-cell Activation and Receptor Signaling Structural, Biochemical, and Biophysical Studies of HLA-A2/Altered Peptide Ligands Bindingto Viral-peptide-specific Human T-cell Receptors B.M. Baker, Y.-H. Ding, D.N. Garboczi, W.E. Biddison, and D.C. Wiley 235 Visualizing T-cell Recognition M.M. Davis, C. Wülfing, M.F. Krummel, P.A. Savage, J. Xu,C. Sumen, M.L. Dustin, and Y.-H. Chien 243 Three Signals and a Master Switch in the Regulation of T-cell Immunity A. Lanzavecchia 253 Studies on the Adapter Molecule LAT L.E. Samelson, S.C. Bunnell, R.P. Trible, T. Yamazaki,and W. Zhang 259 The Adapter Proteins LAT and SLP-76 Are Required for T-cell Activation T.S. Finco,D. Yablonski, J. Lin, and A. Weiss 265 Signaling in Primary Thymocytes after Presentation of Altered Peptide Ligands by Antigen-presenting Cells or MHC-peptide Tetramers L.A. Smyth, L. Reynolds, R. Tyrrell,O. Williams, T. Norton, T. Schumacher, V. Tybulewicz, S.C. Ley, and D. Kioussis 275 The Impact of Pre-T-cell Receptor Signals on Gene Expression in Developing T CellsH. von Boehmer, I. Aifantis, O. Azogui, C. Saint-Ruf, and F. Grassi 283 The PTK-STAT Signaling Pathway Has Essential Roles in T-cell Activation in Response toAntigen Stimulation T. Welte, D. Leitenberg, B.N. Dittel, B.K. al-Ramadi, W.R. Hansen,B. Xie, C.A. Janeway, Jr., A.L.M. Bothwell, K. Bottomly, and X.-Y. Fu 291 CTLA-4 -The Costimulatory Molecule That Doesn't: Regulation of T-cell Responses byInhibition C.A. Chambers and J.P. Allison 303 B-cell Activation and Receptor Signaling Mechanisms of Self-tolerance and Autoimmunity: From Whole-animal Phenotypes toMolecular Pathways C.C. Goodnow, R. Glynne, D. Mack, B. Weintraub, J. Rathmell,J.I. Healy, S. Chaudhry, L. Miosge, A. Loy, and L. Wilson 313 The Maintenance and the Activation Signal of the B-cell Antigen Receptor M. Reth andJ. Wienands 323
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Inhibitory Receptors and Their Modes of Action D.C. Fong and J.C. Cambier 329 Cell Death and Survival in the Immune System Genetic Analysis of Apoptotic and Survival Signals T.W. Mak and W.-C. Yeh 335 Death and Survival Signals Determine Active/Inactive Conformations of Pro-apoptotic BAX,BAD, and BID Molecules S.J. Korsmeyer, A. Gross, H. Harada, J. Zha, K. Wang,X.-M. Yin, M. Wei, and S. Zinkel 343 Control of Apoptosis in Hematopoietic Cells by the Bcl-2 Family of Proteins J.M. Adams,D.C.S. Huang, H. Puthalakath, P. Bouillet, G. Vairo, K. Moriishi, G. Hausmann,L. O'Reilly, K. Newton, S. Ogilvy, M.L. Bath, C.G. Print, A.W. Harris, A. Strasser,and S. Cory 351 RIPs: An Emerging Family of Kinases Involved in Pro-inflammatory and Apoptotic Signaling V.M. Dixit 359 Receptor-mediated Apoptosis in T Lymphocytes J. Zhang, A. DeYoung, H.G. Kasler,N.H. Kabra, A.A. Kuang, G. Diehl, S.J. Sohn, C. Bishop, and A. Winoto 363 Role of the Nuclear Hormone Receptor RORg in Transcriptional Regulation, ThymocyteSurvival, and Lymphoid Organogenesis D.R. Littman, Z. Sun, D. Unutmaz,M.J. Sunshine, H.T. Petrie, and Y.-R. Zou 373 What Keeps a Resting T Cell Alive? C.B. Thompson, J.C. Rathmell, K.A. Frauwirth,T. Lindsten, C.M. Rudin, J.T. Opferman, P.G. Ashton-Rickardt, M.H. Harris, N.S. Chandel,P.T. Schumacker, and M.G. Vander Heiden 383 Cytokine Signaling and Responses Differential Roles of Cytokine Signaling during T-cell Development R. Moriggl,J.-C. Marine, D.J. Topham, S. Teglund, V. Sexl, C. McKay, R. Piekorz, D. Wang,E. Parganas, A. Yoshimura, and J.N. Ihle 389 Negative Regulation of Cytokine Signaling by the SOCS Proteins N.A. Nicola, S.E. Nicholson,D. Metcalf, J.-G. Zhang, M. Baca, A. Farley, T.A. Willson, R. Starr, W. Alexander, andD.J. Hilton 397 IL-4 Signaling Is Regulated through the Recruitment of Phosphatases, Kinases, and SOCSProteins to the Receptor Complex J. Losman, X.P. Chen, H. Jiang, P.-Y. Pan,M. Kashiwada, C. Giallourakis, S. Cowan, K. Foltenyi, and P. Rothman 405 Signaling via the IL-2 and IL-7 Receptors from the Membrane to the Nucleus W.J. Leonard,K. Imada, H. Nakajima, A. Puel, E. Soldaini, and S. John 417 Potential Roles of Stat1 and Stat3 in Cellular Transformation J.F. Bromberg and J.E. Darnell, Jr. 425 Innate Immune Induction of the Adaptive Immune Response R. Medzhitov and C.A. Janeway, Jr. 429 Attenuation of Tumor Necrosis Factor a Gene Transcription in Macrophages by an AutocrineFactor M. Baer, S. Nedospasov, and P.F. Johnson 437 Mechanism of Chromatin Recognition and Transcriptional Regulation by LEF-1 and theWnt/Wg-responsive LEF-1:b-Catenin Complex A. Tutter, G.S. McAlpine, and K.A. Jones 445 HIV and SIV Nef Modulate Signal Transduction and Protein Sorting in T Cells J. Skowronski,M.E. Greenberg, M. Lock, R. Mariani, S. Salghetti, T. Swigut, and A.J. Iafrate 453 Transcription Factor IRF-1 and Its Family Members in the Regulation of Host DefenseT. Taniguchi, N. Tanaka, K. Ogasawara, S. Taki, M. Sato, and A. Takaoka 465 NF-kB/NF-AT/TRAF NF-kB Activation by Tumor Necrosis Factor and Interleukin-1 Z. Cao, M. Tanaka, C. Regnier,M. Rothe, A. Yamit-hezi, J.D. Woronicz, M.E. Fuentes, M.H. Durnin, S.A. Dalrymple,and D.V. Goeddel 473 Role of NF-kB in T-lymphocyte Development R.E. Voll and S. Ghosh 485 The IkB Kinase: A Master Regulator of NF-kB, Innate Immunity, and Epidermal DifferentiationM. Delhase and M. Karin 491 Signaling through Calcium, Calcineurin, and NF-AT in Lymphocyte Activation and DevelopmentK. Stankunas, I.A. Graef, J.R. Neilson, S.-H. Park, and G.R. Crabtree 505 NF-AT5: The NF-AT Family of Transcription Factors Expands in a New Direction C. López-RodrÃÂguez, J. Aramburu, A.S. Rakeman, N.G. Copeland, D.J. Gilbert, S. Thomas, C. Disteche, N.A. Jenkins, and A. Rao 517 Signal Integration by Transcription-factor Assemblies: Interactions of NFAT1 and AP-1 onthe IL-2 Promoter L. Chen, A. Rao, and S.C. Harrison 527 Structure and Mechanism in NF-kB/IkB Signaling T. Huxford, S. Malek, and G. Ghosh 533 Structural Studies of Human TRAF2 H. Wu, Y.C. Park, H. Ye, and L. Tong 541 Structural and Biochemical Analysis of Signal Transduction by the TRAF Family of AdapterProteins S.M. McWhirter, S.S. Pullen, B.G. Werneburg, M.E. Labadia, R.H. Ingraham,J.J. Crute, M.R. Kehry, and T. Alber 551 T-cell Differentiation Molecular Basis of T-cell Differentiation R.A. Flavell, B. Li, C. Dong, H.-T. Lu,D.D. Yang, H. Enslen, C. Tournier, A. Whitmarsh, M. Wysk, D. Conze, M. Rincón,and R.J. Davis 563 Tissue-specific Regulation of Cytokine Gene Expression I.-C. Ho, J.I. Kim, S.J. Szabo,and L.H. Glimcher 573 Bi-stable Transcriptional Circuitry and GATA-3 Auto-activation in Th2 CommitmentK.M. Murphy, W. Ouyang, S. Ranganath, and T.L. Murphy 585 Multiple Levels of Regulation of Th2 Cytokine Gene Expression N. Arai, H.J. Lee, I. Ferber,H. Kurata, and A. O'Garra 589 Bias in the Expression of IL-4 Alleles: The Use of T Cells from a GFP Knock-in MouseC. Pannetier, J. Hu-Li, and W.E. Paul 599 Summary: Signals and Beyond R.A. Flavell 603
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