1989: Immunological Recognition, Vol. LIV
Organizer: James D. Watson, John R. Inglis
Part 1 Symposium Participants v Foreword xxi Introduction Approaching the Asymptote? Evolution and Revolution in Immunology C. A. Janeway, Jr. 1 Implications of the Diversity of the Immunoglobulin Gene SuperfamilyT. Hunkapiller, J. Goverman, B. F. Koop, and L. Hood 15 Lymphocyte Development and Receptor Selection T Cells Diversity, Development, Ligands, and Probable Functions of gd T Cells S. Tonegawa, A. Berns, M. Bonneville, A. Farr, I. Ishida, K. Ito, S. Itohara, C. A. Janeway, Jr., O. Kanagawa, M. Katsuki, R. Kubo, J. Lafaille, P. Mombaerts, D. Murphy, N. Nakanishi, Y. Takagaki, L. Van Kaer, and S. Verbeek 31 A TCR g d Cell Recognizing a Novel TL-encoded Gene Product B. A. Houlden, L. A. Matis, R. Q. Cron, S. M. Widacki, G. D. Brown, C. Pampeno, D. Meruelo, and J. A. Bluestone 45 Phenotypic Analysis of Mice Transgenic for the TCR Cg 4 (Vg 1.1Jg 4Cg 4) Gene D. A. Ferrick, X. Min, D. A. Gajewski, and T. W. Mak 57 T-cell Subpopulations Expressing Distinct Forms of the TCR in Normal, Athymic, and Neonatally TCRab-suppressed Rats T. Hünig, G. Tiefenthaler, A. Lawetzky, R. Kubo, and E. Schlipköter 61 T-cell Development in Birds M. D. Cooper, R. P. Bucy, J. F. George, J. M. Lahti, D. Char, and C.-L. H. Chen 69 Developmental Analysis of the Mouse Hematolymphoid System S. Heimfeld, C. J. Guidos, B. Holzmann, M. H. Siegelman, and I. Weissman 75 Developmental Regulation of the TCRad Locus A. Winoto and D. Baltimore 87 How Important Is the Direct Recognition of Polymorphic MHC Residues by TCR in the Generation of the T-cell Repertoire? P. Kourilsky, J.-M. Claverie, A. Proch-nicka-Chalufour, A.-L. Spetz-Hagberg, and E.-L. Larsson-Sciard 93 T-cell Repertoire and Thymus P. Marrack, M. Blackman, H. G. Burgert, J.M. McCormack, J. Cambier, T. H. Finkel, and J. Kappler 105 Control of T-cell Development by TCRab for Antigen H. von Boehmer, H. Kishi, P. Borgulya, B. Scott, W. van Ewijk, H. S. Teh, and P. Kisielow 111 TCR Recognition and Selection In Vivo M. M. Davis, L. J. Berg, A. Y. Lin, B. Fazekas de St. Groth, B. Devaux, C. G. Sagerström, P. J. Bjorkman, and J. F. Elliott 119 Positive and Negative Selection of the T-cell Antigen Receptor Repertoire in Nontrans-genic Mice H. R. MacDonald, D. Speiser, R. Lees, R. Schneider, R. M. Zinker-nagel, and H. Hengartner 129 A Third Set of Genes Regulates Thymic Selection E. Palmer, D. L. Woodland, M. P. Happ, J. Bill, and O. Kanagawa 135 Positive and Negative Selection of T Lymphocytes D. Y. Loh, W. C. Sha, C. A. Nelson, R. D. Newberry, D. M. Kranz, and J.H. Russell 147 Both TCR/MHC and Accessory Molecule/MHC Interactions Are Required for Positive and Negative Selection of Mature T Cells in the Thymus J. C. Zúñiga-Pflücker, L. A. Jones, D. L. Longo, and A. M. Kruisbeek 153 B Cells Selection of Lymphocyte Repertoires: The Limits of Clonal Versus Network Or-ganization A. Coutinho, A. Bandeira, P. Pereira, D. Portnoi, D. Holmberg, C. Martinez, and A. A. Freitas 159 Control of Cell Growth and Differentiation during Early B-cell Development by Stromal Cell Molecules S.-I. Nishikawa, S.-I. Hayashi, M. Ogawa, T. Kunisada, S. Nishikawa, T. Sudo, H. Nakauchi, and T. Suda 171 Molecular Mechanism for Immunoglobulin Double-isotype Expression A. Shimizu, T. Kinashi, M. C. Nussenzweig, T.-R. Mizuta, P. Leder, and T. Honjo 175 Cellular Stages and Molecular Steps of Murine B-cell Development F. Melchers, A. Strasser, S. R. Bauer, A. Kudo, P. Thalmann, and A. Rolink 183 Control of VDJ Recombinase Activity P. Ferrier, B. Krippl, A. J. Furley, T. K. Blackwell, H. Suh, M. Mendelsohn, A. Winoto, W. D. Cook, L. Hood, F. Costan-tini, and F. W. Alt 191 The Role of Ideotypic Interactions and B-cell Subsets in Development of the B-cell Repertoire J. F. Kearney, M. Vakil, and N. Solvason 203Growth and Selection of B Cells In Vivo K. Rajewsky, H. Gu, P. Vieira, and I. Förster. 209 Conventional and Ly-1 B-cell Lineages in Normal and m Transgenic Mice L. A. Herzenberg and A. M. Stall 219 Templated, Targeted Sequence Diversification Displays a Similar Choreography in Different Organisms V. David and N. Maizels 227 Recognition by Antibodies Comparative Study of Two Fab-lysozyme Crystal Structures D. R. Davies, S. Sheriff, and E. Padlan 233 Immunochemical and Crystallographic Studies of Antibody D1.3 in Its Free, Antigen-liganded, and Idiotope-bound States G. A. Bentley, T. N. Bhat, G. Boulot, T. Fischmann, J. Navaza, R. J. Poljak, M.-M. Riottot, and D. Tello 239 Antibody Recognition of the Influenza Virus Neuraminidase G. M. Air, W. G. Laver, R. G. Webster, M. C. Els, and M. Luo 247 Crystal Structures of Neuraminidase-Antibody Complexes W. R. Tulip, J. N. Vargh-ese, R. G. Webster, G. M. Air, W. G. Laver, and P. M. Colman 257 Generating Binding Activities from Escherichia coli by Expression of a Repertoire of Immunoglobulin Variable Domains D. Güssow, E. S. Ward, A. D. Griffiths, P. T. Jones, and G. Winter 265 A Combinatorial System for Cloning and Expressing the Catalytic Antibody Repertoire in Escherichia coli S. A. Iverson, L. Sastry, W. D. Huse, J. A. Sorge, S. J. Ben-kovic, and R. A. Lerner 273 A New Effector Mechanism for Antibodies: Catalytic Cleavage of Peptide Bonds S. Paul 283 Antigen Recognition by T Cells Antigen Processing Proteolytic Processing in Endosomal Vesicles J. S. Blum, R. Diaz, S. Diment, M. Fiani, L. Mayorga, J. S. Rodman, and P. D. Stahl 287 The Importance of Antigen Processing in Determinant Selection and of the Cell Membrane as a Reservoir of Processed Antigen B. Benacerraf, M. T. Michalek, L. H. Dang, and K. L. Rock 293 A Mutant Cell in Which Association of Class I Heavy and Light Chains Is Induced by Viral Peptides A. Townsend, C. Öhlén, L. Foster, J. Bastin, H.-G. Ljunggren, and K. Kärre 299 Structural and Functional Aspects of HLA Class II Glycoproteins and the Associated Invariant Chain P. Cresswell, J. S. Blum, M. S. Marks, and P. A. Roche 309 Intracellular Colocalization of Molecules Involved in Antigen Processing and Presentation by B Cells F. M. Brodsky, B. Koppelman, J. S. Blum, M. S. Marks, P. Cresswell, and L. Guagliardi 319 Antigen Binding and Processing by B-cell Antigen-presenting Cells: Influence on T- and B-cell Activation T. L. Delovitch, A. H. Lazarus, M. L. Phillips, and J. W. Semple 333 Processing of Immunoglobulin-associated Antigen in B Lymphocytes C. Watts, M. A. West, P. A. Reid, and H. W. Davidson 345 Interactions between Peptides, MHC Molecules, and Lymphocyte Receptors Comparison of Orthorhombic and Monoclinic Crystal Structures of HLA-A2 D. R. Madden, M. A. Saper, T. P. J. Garrett, P. J. Bjorkman, J. L. Strominger, and D. C. Wiley 353 Mutants of HLA-A2 in the Analysis of Its Structure and Function J. L. Strominger, J. Santos-Aguado, S. J. Burakoff, M. A. Vega, F. M. Gotch, P. A. Robbins, and A. J. McMichael 361 Model for the Interaction of T-cell Receptors with Peptide/MHC Complexes P. J. Bjorkman and M. M. Davis 365 T-cell Recognition of Superantigens: Inside or Outside the Groove? P. Dellabona, J. Peccoud, C. Benoist, and D. Mathis 375 Antigen-binding Function of Class II MHC Molecules E. R. Unanue, C. V. Harding, I. F. Luescher, and R. W. Roof 383 Studies on the Nature of Physiologically Processed Antigen and on the Conformation of Peptides Required for Interaction with MHC H. M. Grey, S. Demotz, S. Buus, and A. Sette 393 Consequences of Self and Foreign Superantigen Interaction with Specific Vb Elements of the Murine TCRab J. W. Kappler, A. Pullen, J. Callahan, Y. Choi, A. Herman, J. White, W. Potts, E. Wakeland, and P. Marrack 401 Structural Intermediates in the Reactions of Antigenic Peptides with MHC Mole-cules K. Dornmair, B. Rothenhäusler, and H. M. McConnell 409 Molecular Studies of Antigen Processing and Presentation to T Cells by Class II MHC Molecules J. A. Berzofsky, A. Kurata, H. Takahashi, S. J. Brett, and D. J. McKean 417 Structural Analysis of a Peptide-HLA Class II Complex J. B. Rothbard, R. Busch, C. M. Hill, and J. R. Lamb 431 Study on the Immunogenicity of Human Class II-restricted T-cell Epitopes: Processing Constraints, Degenerate Binding, and Promiscuous Recognition P. Panina-Bordignon, S. Demotz, G. Corradin, and A. Lanzavecchia 445 Binding of Self-antigens to Ia Molecules R. G. Lorenz, J. S. Chen, S. G. Williams, and P. M. Allen 453 Molecular Studies of Human Response to Allergens D. G. Marsh, P. Zwollo, S. K. Huang, B. Ghosh, and A. A. Ansari 459Monoclonal Antibodies and the Epitope Distribution of HLA Class II Polymorphisms J. G. Bodmer, S. G. E. Marsh, and J. M. Heyes 471
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T-lymphocyte Recognition of a Membrane Glycoprotein T. J. Braciale, M. T. Sweet-ser, L. R. Brown, and V. L. Braciale 477B- and T-cell Recognition of Influenza Hemagglutinin D. B. Thomas, D. S. Burt, B. C. Barnett, C. M. Graham, and J. J. Skehel 487 Control of Cellular and Humoral Immune Responses by Peptides Containing T-cell Epitopes M. T. Scherer, B. M. C. Chan, F. Ria, J. A. Smith, D. L. Perkins, and M. L. Gefter 497 Examining the Crypticity of Antigenic Determinants A. Ametani, R. Apple, V. Bhar-dwaj, G. Gammon, A. Miller, and E. Sercarz 505 Expression and Function of Human Major Histocompatibility Complex HLA-DQw6 Genes in the C57BL/6 Mouse T. Sasazuki, T. Iwanaga, T. Inamitsu, Y. Yanagawa, M. Yasunami, A. Kimura, K. Hirokawa, and Y. Nishimura 513 Use of Mutants to Analyze Regions on the H-2Kb Molecule for Interaction with Immune Receptors S. G. Nathenson, K. Kesari, J. Sheil, and P. Ajitkumar 521 Diversity of Class I HLA Molecules: Functional and Evolutionary Interactions with T Cells P. Parham, R. J. Benjamin, B. P. Chen, C. Clayberger, P. D. Ennis, A. M. Krensky, D. A. Lawlor, D. R. Littman, A. M. Norment, H. T. Orr, R. D. Salter, and J. Zemmour 529 Structural Features of Peptides Recognized by H-2Kd-restricted T Cells J. L. Maryan-ski, J.-P. Abastado, G. Corradin, and J.-C. Cerottini 545 Class I MHC-restricted Cytotoxic Responses to Soluble Protein Antigen F. R. Car-bone, N. A. Hosken, M. W. Moore, and M. J. Bevan 551 A Peptide Derived from the a-Helical Region of Class I MHC Blocks CTL Engagement of the Class I MHC Molecule T. I. Munitz, J. Schneck, J. E. Coligan, W. L. Maloy, J. P. Henrich, S. O. Sharrow, D. H. Margulies, and A. Singer 557 Molecular Definition of a Mitochondrially Encoded Mouse Minor Histocompatibility Antigen K. Fischer Lindahl, E. Hermel, B. E. Loveland, S. Richards, C.-R. Wang, and H. Yonekawa 563 Cloning and Expression of the Neonatal Rat Intestinal Fc Receptor, a Major Histocom-patibility Complex Class I Antigen Homolog N. E. Simister and K. E. Mostov 571 Variation in HLA Expression on Tumors: An Escape from Immune Response M. E. F. Smith, J. G. Bodmer, A. P. Kelly, J. Trowsdale, S. C. Kirkland, and W. F. Bodmer. 581 Genes Coding for T-cell-defined Tum- Transplantation Antigens: Point Mutations, Antigenic Peptides, and Subgenic Expression T. Boon, A. Van Pel, E. De Plaen, P. Chomez, C. Lurquin, J.-P. Szikora, C. Sibille, B. Mariamé, B. Van den Eynde, B. Lethé, and V. Brichart 587 Immunosurveillance of Virus-induced Tumors C. J. M. Melief, W. L. E. Vasmel, R. Offringa, E. J. A. M. Sijts, E. A. Matthews, P. J. Peters, R. H. Meloen, A. J. van der Eb, and W. M. Kast 597 Part 2 Signals for Lymphocyte Activation, Proliferation, and Adhesion T-cell Clonal Anergy R. H. Schwartz, D. L. Mueller, M. K. Jenkins, and H. Quill 605 The Biology of Human CD2 E.L. Reinherz, H.-C. Chang, L. K. Clayton, P. Gardner, F. D. Howard, S. Koyasu, Y.-J. Jin, P. Moingeon, and P. H. Sayre 611 Structure-Function Relationships of the Human T Lymphocyte CD2 Antigen M.H. Brown, E. Monostori, M. Gullberg, R. Zamoyska, G. Lang, D. Kioussis, and M. J. Crumpton 627 Structural Diversity in Domains of the Immunoglobulin Superfamily A. F. Williams, S. J. Davis, Q. He, and A. N. Barclay 637 Role of CD4 and CD8 in Enhancing T-cell Responses to Antigen J. R. Parnes, P. von Hoegen, M. C. Miceli, and R. Zamoyska 649 Cross-linking and Conformational Change in T-cell Receptors: Role in Activation and in Repertoire Selection C. A. Janeway, Jr., U. Dianzani, P. Portoles, S. Rath, E.-P. Reich, J. Rojo, J. Yagi, and D. B. Murphy 657 Problems in the Physiology of Class I and Class II MHC Molecules, and of CD4 A. G. Fisher, L. K. Goff, L. Lightstone, J. Marvel, N. A. Mitchison, G. Poirier, H. Stauss, and R. Zamoyska 667 Studies on the Leukocyte-common Antigen: Structure, Function, and Evolutionary Conservation R. J. Matthews, J. T. Pingel, C. M. Meyer, and M. L. Thomas 675 Cell Membrane Molecule I-J Transduces a Negative Signal for Early T-cell Activation Induced via the TCR Y. Asano, T. Nakayama, H. Kishimoto, T. Komuro, K. Sano, N. Utsunomiya, M. Nakanishi, and T. Tada 683 Interleukin-2 Receptor b Chain: Molecular Cloning and Functional Expression of the Human cDNA T. Taniguchi, M. Hatakeyama, S. Minamoto, T. Kono, T. Doi, M. Tsudo, M. Miyasaka, and T. Miyata 689 Immune Dysfunctions and Activation of Natural Killer Cells in Human IL-2 and IL-2/IL-2 Receptor L-chain Transgenic Mice Y. Ishida, M. Nishi, O. Taguchi, K. Inaba, N. Minato, M. Kawaichi, and T. Honjo 695 Regulation of the Biological Effects of IL-4 on Murine T and B Cells F. Ferdandez-Botran, V. M. Sanders, and E. S. Vitetta 705 Interleukin-6 Receptor and a Unique Mechanism of Its Signal Transduction T. Taga, M. Hibi, Y. Hirata, H. Yawata, S. Natsuka, K. Yasukawa, T. Totsuka, K. Yamasaki, T. Hirano, and T. Kishimoto 713 Regulation of the Polyphosphoinositide-specific Phosphodiesterase in B Lym-phocytes G. G. B. Klaus, M. M. Harnett, and K. P. Rigley 723 Signal Transduction by the Antigen Receptor of B Lymphocytes A. L. DeFranco, D. M. Page, J. H. Blum, and M. R. Gold 733 Three B-cell-surface Molecules Associating with Membrane Immunoglobulin R. M. E. Parkhouse 741 Signal Transduction through Interleukin-5 Receptors K. Takatsu, N. Yamaguchi, Y. Hitoshi, E. Sonoda, S. Mita, and A. Tominaga 745 Structure and Regulation of the Leukocyte Adhesion Receptor LFA-1 and Its Counter-receptors, ICAM-1 and ICAM-2 M.L. Dustin, J. Garcia-Aguilar, M. L. Hibbs, R. S. Larson, S. A. Stacker, D. E. Staunton, A. J. Wardlaw, and T. A. Springer 753 Transcriptionally Defective Retroviruses Containing lacZ for the In Situ Detection of Endogenous Genes and Developmentally Regulated Chromatin W. G. Kerr, G. P. Nolan, A. T. Serafini, and L. A. Herzenberg 767 Tolerance and Self Recognition Induction of Tolerance by Embryonic Thymic Epithelial Grafts in Birds and Mam-mals N. M. Le Douarin, C. Corbel, C. Martin, M. Coltey, and J. Salaün 777 T-cell Tolerance to H-2 Molecules: Role of the Thymus J. Sprent, E.-K. Gao, and S. R. Webb 789 Activation Versus Tolerance: A Decision Made by T Helper Cells S. Guerder and P. Matzinger 799 Extrathymic Acquisition of Tolerance by T Lymphocytes J. F. A. P. Miller, G. Morahan, and J. Allison 807 Clonal Anergy of I-E-tolerant T Cells in Transgenic Mice with Pancreatic Expression of MHC Class II I-E L. C. Burkly, D. Lo, O. Kanagawa, R. L. Brinster, and R. A. Flavell 815 Alternative Self or Nonself Recognition of an Antigen Expressed in a Rare Cell Type in Transgenic Mice: Implications for Self-tolerance and Autoimmunity D. Hanahan, C. Jolicoeur, S. Alpert, and J. Skowronskið. 821 Inflammatory Destruction of Panacreatic b Cells in g-Interferon Transgenic Mice N. Sarvetnick, J. Shizuru, D. Liggitt, and T. Stewart 837 Reactivity and Tolerance of Virus-specific T Cells R. M. Zinkernagel, H. P. Pircher, M. Schulz, T. Leist, S. Oehen, and H. Hengartner 843 Evolution, Function, and Utilization of Major Histocompatibility Complex Polymorphism in Autoimmune Disease H. O. McDevitt, D. C. Wraith, D. E. Smilek, A. S. Lundberg, and L. Steinman 853 Autoimmune Disease and T-cell Immunologic Recognition L. Hood, V. Kumar, G. Osman, S. S. Beall, C. Gomez, W. Funkhouser, D. H. Kono, D. Nickerson, D. M. Zaller, and J. L. Urban 859 A New Hierarchy of TCR Specificity: Autoimmune Diseases Are Defined by Particular Va Vb Combinations and Not by Antigen Specificity E. Heber-Katz 875 Physiological Basis of T-cell Vaccination against Autoimmune Disease I. R. Cohen 879 Tolerance Induction in the Adult Using Monoclonal Antibodies to CD4, CD8, and CD11a (LFA-1) H. Waldmann, S. P. Cobbold, S. Qin, R. J. Benjamin, and M. Wise 885 Immunologic Tolerance within the B-lymphocyte Compartment: An Adult Tolerance Model G. J. V. Nossal, M. Karvelas, and P. A. Lalor 893 Models of B-cell Unresponsiveness D. W. Scott, J. E. Alés-MartÃÂnez, J. H. Chace, N. J. LoCascio, L. Silver, and G. L. Warner 899 Clonal Silencing of Self-reactive B Lymphocytes in a Transgenic Mouse Model C. C. Goodnow, J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, D. Y. Mason, H. Jorgensen, R. A. Brink, H. Pritchard-Briscoe, M. Loughnan, R. H. Loblay, R. J. Trent, and A. Basten 907 Impact of Somatic Mutation on the S107 (T15) Heavy-chain V Region of Antibodies Reactive with Self and Nonself S. M. Behar, N. C. Chien, S. Corbet, B. Diamond, E. D. Getzoff, D. Lustgarten, V. A. Roberts, M. D. Scharff, and S.-U. Shin 921 Structural Patterns in Anti-DNA Antibodies from MRL/lpr Mice M. Z. Radic, M. A. Mascelli, J. Erikson, H. Shan, M. Shlomchik, and M. Weigert 933 Summary Summary: The New Pragmatics of Immunology J. C. Howard 947
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