1988: Molecular Biology of Signal Transduction, Vol. LIII
Organizer: James Watson
Part 1 Symposium Participants v Foreword xix Bacterial Chemotaxis A Physicist Looks at Bacterial Chemotaxis H. C. Berg 1 Roles of Methylation and Phosphorylation in the Bacterial Sensing System D. E. Koshland, Jr., D. A. Sanders, and R. M. Weis 11 Osmotaxis in Escherichia coli J. Adler, C. Li, A. I. Boileau, Y. Qi, and C. Kung 19 Galvanotaxis in Bacteria J. Adler and W Shi 23Interaction of CheB with Chemotaxis Signal Transduction Components in Escherichia coli: Modulation of the Methylesterase Activity and Effects on Cell Swimming Behavior R. C. Stewart, C. B. Russell, A. F. Roth, and F. W Dahlquist 27 Protein Phosphorylation and Bacterial Chemotaxis J. F. Hess, R. B. Bourret, K. Oosawa, P. Matsumura, and M. I. Simon 41 Phosphoproteins Involved in Bacterial Signal Transduction A. M. Stock, D. C. Wylie, J. M. Mottonen, A. N. Lupas, E. G. Ninfa, A. F. Ninfa, C. E. Schutt, and I. B. Stock 49Structure-Function Studies of Bacterial Chemosensors P. Ames, I. Chen, C. Wolff and I. S. Parkinson 59 The End of the Line in Bacterial Sensing: The Flagellar Motor R. M. Macnab 67 Protein Phosphorylation Casein Kinase II as a Potentially Important Enzyme Concerned with Signal Transduc- tion E.G. Krebs, R. N. Eisenman, E. A. Kuenzel, D. W Litchfield, F. I. Lozeman,B. Luscher, and I. Sommercorn 77 Microinjection of the Catalytic Subunit of cAMP-dependent Protein Kinase Induces Expression of the c-fos Gene K. T. Riabowol, M. Z. Gilman, and I. R. Feramisco 85 Regulating Cell Growth: Casein-kinase-Il-dependent Phosphorylation of Nuclear On- coproteins D. Carroll, N. Santoro, and D. R. Marshak 91 The Family of Protein Kinase C: Its Molecular Heterogeneity and Differential Expres- sion U. Kikkawa, K. Ogita, M. S. Shearman, K. Ase, K. Sekiguchi, Z. Naor, A. Kishimoto, Y. Nishizuka, N. Saito, C. Tanaka, Y. Ono, T. Fujii, and K. Igarashi 97 Protein Kinase C Regulation by Sphingosine/Lysosphingolipids R. M. Bell, C. R.Loomis, and Y. A. Hannun 103 Expression of Wild-type and Mutant Subunits of the cAMP-dependent ProteinKinase G. S. McKnight, G. G. Cadd, C. H. Clegg, A. D. Otten, and L. A. Correll 111 cAMP-dependent Protein Kinase: A Framework for a Diverse Family of EnzymesS.S. Taylor, I. A. Buechler, L. W. Slice, D. K. Knighton, S. Durgerian, G.E.Ringheim, I .I. Neitzel, W. M. Yonemoto, I. M. Sowadski, and W. Dospmann 121 Targets for Signal-transducing Protein Kinase T. Hunter, P. Angel, W. I. Boyle, R.Chiu, E. Freed, K. L. Gould, C. M. Isacke, M. Karin, R. A. Lindberg, and P. vander Geer 131 Molecular Analyses of Gene Products Associated with the Response of Cells to Mitogenic Stimulation R. L. Erikson, D. Alcorta, P. -A. Bedard, I. Blenis, H. -P. Biemann, E. Erikson, S. W. Jones, I. L. MaIler, T. J. Martins, and D. L. Simmons . 143 Interactions between the Middle T Antigen of Polyomavirus and Host Cell Proteins S. A. Courtneidge, R. M. Kypta, and E. T. Ulug 153 Tyrosine Phosphorylation in Signal Transduction T. M. Roberts, D. Kaplan, W. Mor- gan, T. Keller, H. Mamon, H. Piwnica Worms, B. Druker, B. Cohen, B. Schaff hausen, M. Whitman, L. Cantley, U. Rapp, and D. Morrison 161 raf Family Serine/Threonine Protein Kinases in Mitogen Signal Transduction U. R. Rapp, G. Heidecker, M. Huleihel, J. L. Cleveland, W. C. Choi, T. Pawson, J. N. Ihle, and W. B. Anderson 173 Calmodulin and Calmodulin-regulated Protein Kinases as Transducers of Intracellular Calcium Signals T. J. Lukas, J. Haiech, W. Lau, T. A. Craig, W. E. Zimmer, R. L. Shattuck, M. O. Shoemaker, and D. M. Watterson 185 Regulation of the Vertebrate Cell Cycle by the cdc2 Protein Kinase G. Draetta, L. Brizuela, B. Moran, and D. Beach 195 Mechanism of Action of G Proteins Role of G Proteins in Transmembrane Signaling P. J. Casey, M. P. Graziano, M. Freissmuth, and A. G. Gilman 203 Structure of the Genes Coding for G-protein a Subunits from Mammalian and Yeast Cells Y. Kaziro, H. Itoh, T. Kozasa, R. Toyama, T. Tsukamoto, M. Matsuoka, M. Nakafuku, T. Obara, T. Takagi, and R. Hernandez 209 Mutations Probe Structure and Function of G-protein a Chains H. R. Bourne, S. B. Masters, R. T. Miller, K. A. Sullivan, and W. Heideman 221 Receptor-effector Coupling by G Proteins: Purification of Human Erythrocyte Gi-2 and Gi-3 and Analysis of Effector Regulation Using Recombinant a Subunits Synthe- sized in Escherichia coli L. Birnbaumer, J. Codina, R. Mattera, A. Yatani, R. Graf, J. Olate, J. Sanford, and A. M. Brown 229 Functions of G-protein Subunits E. J. Neer, S. -Y. Kim, S. -L. Ang, D. B. Bloch, K. D. Bloch, Y. Kawahara, C. Tolman, R. Lee, D. Logothetis, D. Kim, J. G. Seidman, and D. E. Clapham 241 Receptor- and G-Protein-mediated Modulations of Voltage-dependent Calcium Chan- nels W. Rosenthal, J. Hescheler, W. Trautwein, and G. Schultz 247 Unique Properties of a New GTP-binding Protein with a Molecular Mass of 24,000 Daltons Purified from Porcine Brain Membranes T. Katada and M. Ui 255 Functional Role of Muscarinic Acetylcholine Receptor Subtype Diversity A. Ashken- azi, E. G. Peralta, J. W. Winslow, J. Ramachandran, and D. J. Capon . 263 ras Oncogene Proteins: Three-dimensional Structures, Functional Implications, and a Model for Signal Transducer S.-H. Kim, A. M. tIe Vos, L. Tong, M. V. Milburn, P. M. Matias, J. Jancarik, E. Ohtsuka, and S. Nishimura 273 Mechanisms of Neurosensory Transduction Molecular Basis of Visual Excitation L. Stryer 283 Molecular Basis of the Functional Heterogeneity of the Muscarinic Acetylcholine Receptor S. Numa, K. Fukuda, T. Kubo, A. Maeda, I. Akiba, H. Bujo, J. Nakai, M. Mishina, and H. Higashida 295 Life, Evolution, and the Pursuit of Single Photon Sensitivity M. W. Bitensky, M. M. Whalen, and D. C. Torney 303 Visual Signal Transduction: The Cycle of Transducin Shuttling between Rhodopsin and cOMP Phosphodiesterase M. Chabre, J. Bigay, F. Bruckert, F. Bornancin, P. Deterre, C. Pfister, and T. M. Vuong 313 Molecular Mechanics of the Cyclic-GMP-activated Channel of Retinal Rods J. W. Karpen, A. L. Zimmerman, L. Stryer, and D. A. Baylor 325 Inositol Lipid Cascade of Vision Studied in Mutant Flies Z. Selinger and B. Minke ø. 333 Molecular Transduction in Smell and Taste D. Lancet, D. Lazard, J. Heldman, M. Khen, and P. Nef 343 Expression of G-protein a Subunits in Rat Olfactory Neurcepithelium: Candidates for Olfactory Signal Transduction D. T. Jones, E. Barbosa, and R. R. Reed 349 Studies on Light Transduction by Bactenorhodopsin and Rhodopsin M. Braiman, J.Bubis, T. Doi, H. -B. Chen, S. L. Flitsch, R. R. Franke, M. A. Gilles-Gonzalez,R. M. Graham, S.S. Karnik, H. G. Khorana, B. E. Knox, M. P. Krebs, T. Marti, T.Mogi T. Nakayama, D. D. Oprian, K. L. Puckett, T. P. Sakmar, L. J. Stern, S. Subramaniam, and D. A. Thompson 355 Direct Coupling of 0 Proteins to Ionic Channels A. M. Brown, A. Yatani, Y. Imoto, G. Kirsch, H. Hamm, J. Codina, R. Mattera, and L. Birnbaumer 365 Role of G-protein-coupled Phosphatidylinositol System in Signal Transduction in Ver- tebrate Neurons: Experiments on Neuroblastoma Hybrid Cells and Ganglion Cells D. A. Brown, H. Higashida, P. R. Adams, N. V. Marrion, and T. G. Smart 375 Functional Expression of the 5-HT1C Receptor in Neuronal and Nonneuronal Cells D. Julius, A. B. MacDermott, T. M. Jessell, K. Huang, S. Molineaux, I. Schieren, and R. Axel 385 Molecular Convergence of Presynaptic Inhibition and Presynaptic Facilitation on Com- mon Substrate Proteins of Individual Sensory Neurons of Aplysia D. Sweatt, A. Volterra, S. A. Siegelbaum, and E. R. Kandel 395Electrical and Biochemical Properties of the cOMP-gated Cation Channel from Rod Photoreceptors U. B. Kaupp, W. Hanke, R. Simmoteit, and H. Lühring 407 Sevenless, a Gene Encoding a Putative Receptor for Positional Information G. M. Rubin 417 The Role of Arachidonic Acid Metabolites in Signal Transduction in an Identified Neural Network Mediating Presynaptic Inhibition in Aplysia E. Shapiro, D. Piomelli, S. Feinmark, S. Vogel, G. Chin, and J. H. Schwartz 425 Molecular Mechanisms of Phospholipid Signaling Pathways in Mammalian Nerve Cells M. R. Hanley, T. R. Jackson, W. T. Cheung, M. Dreher, A. Gatti, P. Haw- kins, S. I. Patterson, M. Vallejo, A. P. Dawson, and O. Thastrup 435 Growth Factor and Hormone Receptors Purification and Characterization of Placental Membrane Phosphotyrosine Phos phatases C. J. Pallen, L. Sahlin, G. Panayotou, and M. D. Waterfield 447 Signal Transduction by the Platelet-derived Growth Factor Receptor L. T. Williams, J. A. Escobedo, M. T. Keating, and S. R. Coughlin 455 Role of Intrinsic Protein Tyrosine Kinase in Function and Metabolism of the Epidermal Growth Factor Receptor G. N. Gill, W. S. Chen, C. S. Lazar, J. R. Glenney, Jr., H. S. Wiley, H. A. Ingraham, and M. G. Rosenfeld 467 Molecular Analysis of the Nerve Growth Factor Receptor B. Hempstead, N. Patil, K. Olson, and M. Chao 477 Structure-Function Analysis of the b-Adrenergic Receptor R. A. F. Dixon, L. S. Sigal, and C. D. Strader 487 Functional Domains in the b-Adrenergic Receptor E. M. Ross, S. K. -F. Wong, R. C. Rubenstein, and T. Higashijima 499 Molecular Biology of Adrenergic Receptors R.. J. Lefkowitz, B. K. Kobilka, J. L. Benovic, M. Bouvier, S. Cotecchia, W Hausdorff, H. G. Dohlman, J. W. Regan, and M. G. Caron 507 Signal Transduction by Epidermal Growth Factor Receptor J. Schlessinger, A. UI- Irich, A. M. Honegger, and W. H. Moolenaar 515 Macrophage Colony-stimulating Factor, CSF-1, and Its Proto-oncogene-encoded Re- ceptor C. J. Sherr, C. W. Rettenmier, and M. F. Roussel 521 Platelet-derived Growth Factor Generates at Least Two Distinct Intracellular Signals That Modulate Gene Expression S. D. Jones, D. J. Hall, B. J. Rollins, and C. D. Stiles 531 Insulin and Insulin-like Growth Factor Receptors and Responses R. A. Roth, G. Steele-Perkins, J. Han, C. Stover, S. Pierce, J. Turner, J. C. Edman, and W. J. Rutter 537 Response and Binding Elements for Ligand-dependent Positive Transcription Factors Integrate Positive and Negative Regulation of Gene Expression M. G. Rosenfeld, C. K. Glass, S. Adler, E. B. Crenshaw III, X. He, S. A. Lira, H.P. Elsholtz, H. J. Mangalam, J. M. Holloway, C. Nelson, V. R.. Albert, and H. A. Ingraham 545 PART 2 Signal Transduction in Unicellular Eukaryotes
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From Membrane to Nucleus: The Pathway of Signal Transduction in Yeast and Its Genetic Control L. Marsh and I. Herskowitz 557 The Role of G Proteins in Yeast Signal Transduction K. Matsumoto, M. Nakafuku, N. Nakayama, L Miyajima, K. Kaibuchi, A. Miyajima, C. Brenner, K. Arai, and Y. Kaziro 567 Analysis of the Role of SCG1, a Ga Homolog, and SST2 in Pheromone Response and Desensitization in Yeast J. Kurjan and C. Dietzel 577 Function of the STE4 and 5TE18 Genes in Mating Pheromone Signal Transduction in Saccharomyces cerevisiae M. Whiteway, L. Hougan, D. Dignard, L. Bell, G. Saari, F. Grant, P. O'Hara, V. L. MacKay, and D. Y. Thomas 585 Functional Domains of a Peptide Hormone Receptor: The a-Factor Receptor (STE2 Gene Product) of the Yeast Saccharomyces cerevisiae K. J. Blumer, J. E. Reneke, W. E. Courchesne, and J. Thorner 591 Recovery from Pheromone-induced Arrest of the Yeast Cell Cycle: a-Factor Binding and Mutants That Show Pheromone-independent Arrest of Cell Division D. Blinder, P. Spatrick, S. Bouvier, C. Sullivan, and D. Jenness 605 Response of Yeast a Cells to a-Factor Pheromone: Topology of the Receptor and Identification of a Component of the Response Pathway K. L. Clark, N. G. Davis, D. K. Wiest, J. -J. Hwang-Shum, and G. F. Sprague, Jr 611 Isolation and Characterization of Two Genes Encoding Yeast Mating Pheromone Signaling Elements: CDC72 and CDC73 S. I. Reed, J. Ferguson, and K.-Y. Jahng 621 Diverse Biological Functions of Small GTP-binding Proteins in Yeast D. Botstein, N. Segev, T. Stearns, M. A. Hoyt, J. Holden, and R. A. Kahn 629 Regulation of Vesicular Traffic by a GTP-binding Protein on the Cytoplasmic Surface of Secretory Vesicles in Yeast P. J. Novick, B. Goud, A. Salminen, N. C. Walworth, J. Nair, and M. Potenza 637 Studies of RAS Function in the Yeast Saccharomyces cerevisiae M. Wigler, J. Field, S. Powers, D. Broek, T. Toda, S. Cameron, J. Nikawa, T. Michaeli, J. Colicelli, and K. Ferguson 649 cAMP Receptor and G-protein Interactions Control Development in Dictyo- stelium M. Pupillo, P. Klein, R. Vaughan, G. Pitt, P. Lilly, T. Sun, P. Devreotes, A. Kumagai, and R. Firtel 657 Ion Channels in Paramecium, Yeast, and Escherichia coli Y. Saimi, B. Martinac, M. C. Gustin, M. R. Culbertson, J. Adler, and C. Kung 667 A Molecular Analysis of 0 Proteins and Control of Early Gene Expression by the Cell- surface cAMP Receptor in Dictyostelium A. Kumagai, S. K. O. Mann, M. Pupillo, G. Pitt, P N. Devreotes, and R. A. Firtel 675 Signal Transduction in the Nucleus jun: Oncogene and Transcriptional Regulator A. R. Ball, Jr., T. J. Bos, C. Löliger, L. P Nagata, T. Nishimura, H. Su, H. Tsuchie, and P. K. Vogt 687 Transcriptional Regulation by the AP-1 Family of Enhancer-binding Proteins: A Nu- clear Target for Signal Transduction D. Bohmann, A. Admon, D. R. Turner, and R. Tjian 695 Transcriptional Activation by Yeast GCN4, a Functional Homolog to the jun Onco- protein K. Struhl, C. J. Brandl, W Chen, P. A. B. Harbury, I. A. Hope, and S. Mehadevan 701 YAPi Encodes a Yeast Homolog of Mammalian Transcription Factor AP-1 W. S. Moye-Rowley, K. D. Harshman, and C. S. Parker 711 Analysis of Serum Response Element Function In Vitro C. Norman and R. Treisman 719 Gene Regulation by Growth Factors R. Metz, J. Gorham, Z. Siegfried, D. Leonard, E. Gizang-Ginsberg, M. A. Thompson, D. Lawe, T. Kouzarides, R. Vosatka, D. MacGregor, S. Jamal, M. E. Greenberg, and E. B. Ziff 727 Transcriptional Regulation of c-fos R. Prywes, T. M. Fisch, and R. G. Roeder 739 Regulation of Proto-oncogene fos: A Paradigm for Early Response Genes P. Sassone- Corsi, W W Lamph, and I. M. Verma 749 Intracellular Mediators of c-fos Induction M. Z. Gilman, L. A. Berkowitz, J. R. Feramisco, B. R. Franza, Jr., R. M. Graham, K. T. Riabowol, and W. A. Ryan, Jr. 761 Beyond the Second Messenger: Oncogenes and Transcription Factors T. Curran, F. J. Rauscher III, D. R. Cohen, and B. R. Franza, Jr. 769 Nuclear Oncoproteins Determine the Genetic Program in Response to External Stimuli A. Schönthal, S. Gebel, B. Stein, H. Ponta, H. J. Rahmsdorf, and P. Herrlich 779 Phorbol-ester-induced Activation of the NF-KB Transcription Factor Involves Dissocia- tion of an Apparently Cytoplasmic NF-KB/Inhibitor Complex P. A. Baeuerle, M. Lenardo, J. W. Pierce, and D. Baltimore 789 Transcriptional Regulation of Interferon-stimulated Genes: A DNA Response Element and Induced Proteins That Recognize It D. Levy, N. Reich, D. Kessler, R. Pine, and J. E. Darnell, Jr. 799 Steroid Hormone Receptors Ligand-regulated Nonspecific Inactivation of Receptor Function: A Versatile Mecha nism for Signal Transduction K. R. Yamamoto, P. J. Godowski, and D. Picard 803 Cooperative and Positional Independent trans-Activation Domains of the Human Glucocorticoid Receptor R. M. Evans and S. M. Hollenberg 813 Expression and Function of the Human Estrogen Receptor in Yeast J. H. White, D. Metzger, and P. Chambon 819 Cooperative Interactions of Steroid Hormone Receptors with Their Cognate Response Elements M. -J. Tsai, S. Y. Tsai, L. Klein-Hitpass, M. Bagchi, J. F. Elliston, J. Carlstedt-Duke, J. K. Gustafsson, and B. W. O'Malley 829 Cooperative Action of the Glucocorticoid Receptor and Transcription Factors U. Strähle, A. Münsterberg, R. Mestril, G. Klock, W. Ankenbauer, W. Schmid, and G. Schiitz 835 Growth Control in Mammalian Cells Anti-oncogenes and the Negative Regulation of Cell Growth J. M. Horowitz, S. H. Friend, R. A. Weinberg, P. Whyte, K. Buchkovich, and E. Harlow 843 Interaction of ras p21 Proteins with GTPase Activating Protein F. McCormick, H. Adari, M. Trahey, R. Halenbeck, K. Koths, G. A. Martin, W. Crosier, K. Watt, B. Rubinfeld and G. Wong 849 Analysis of Mammalian ras Effector Function A. Hall, C. Calés, J. F. Hancock, A. Lloyd, A. Self, S. Gardener, M. D. Houslay, M. J. O. Wakelam, and C. J. Marshall 855 Structure/Function Studies of the ras Protein I. S. Sigal, M. S. Marshall, M. D. Schaber, U. S. Vogel, E. M. Scolnick, and J. B. Gibbs 863 Critical Role of Cellular ras Proteins in Proliferative Signal Transduction D. W Stacey, M.-H. Tsai, C.-L. Yu, and J. K. Smith 871 Influence of p2lras on Phosphatidylinositol Turnover J. Downward and R. A. Weinberg 8 883 Genomic Response to Growth Factors D. Nathans, L. F. Lau, B. Christy, S. Hartzell, Y. Nakabeppu, and K. Ryder 893 Identification of Growth-factor-inducible Genes in Mouse Fibroblasts R. Bravo, M. Zerial, L. Toschi, M. Schurmann, R. Muller, S. I. Hirai, M. Yaniv, J. M. Almendral, and R.-P. Ryseck 901 Characterization of p47gag-crk, a Novel Oncogene Product with Sequence Similarity to a Putative Modulatory Domain of Protein-Tyrosine Kinases and Phospholipase C. B. J. Mayer, M. Hamaguchi, and H. Hanafusa 907 Phospholipase C-148: Chromosomal Location and Deletion Mapping of Functional Domains A. Bristol, S. M. Hall, R. W. Kriz, M. L. Stahl, Y. S. Fan, M. G. Byers, R. L. Eddy, T. B. Shows, and J. L. Knopf 915 Primary Structure of PLC-154 M. Katan, R. W. Kriz, N. Tony, R. Phi Ip, E. Meldrum, R. A. Aldape, J. Knopf, and P. J. Parker 921 Second Messenger Systems Inositol Trisphosphate and Calcium Signaling M. J. Berridge and C. W. Taylor 927 Agonist-induced Calcium Oscillations in Depolarized Fibroblasts and Their Manipula- tion by Photoreleased Ins(1,4,5)P3, Ca++, and Ca++ Buffer A. T. Harootunian, J. P. Y. Kao, and R. Y. Tsien 935 Signal Transduction in Mitogenesis: Further Evidence for Multiple Pathways E. Rozengurt, J. Erusalimsky, H. Mehmet, C. Morris, E. Ndnberg, and J. Sinnett- Smith 945 Role of Glycosyl Phosphoinositides in Insulin Action A. R. Saltiel, D. G. Osterman, and J. C. Darnell 955 Insulin Mediators: Structure and Formation J. Lamer, L. C. Huang, G. Tang, S. Suzuki, C. F. W. Schwartz, G. Romero, Z. Roulidis, K. Zeller, T. Y. Shen, A. S. Oswald, and L. Luttrell 965 Gram-negative Endotoxin: A Biologically Active Lipid C. R. H. Raetz, K. A. Brozek, T. Clementz, J. D. Coleman, S. M. Galloway, D. T. Golenbock, and R. Y. Hampton 973 GTP-binding Proteins in the Control of Exocytosis B. D. Gomperts and P. E. R. Tatham 983 The Membrane Form of Guanylate Cyclase D. L. Garbers, D. G. Lowe, L. J. Dangott, M. Chinkers, D. S. Thorpe, J. K. Bentley, C. S. Ramarao, D. V. Goeddel, and S. Singh 993 Effects of Nitrovasodilators, Endothelium-dependent Vasodilators, and Atrial Peptides on cGMP F. Murad, D. Leitman, S. Waldman, C.-H. Chang, M. Hirata, and K. Kohse 1005 Molecular Cloning of the Growth-factor-activatable Human Na+/H+ Antiporter C. Sardet, A. Franchi, and J. Pouysségur 1101 Summary Summary: Signals Past, Present, and Future H.R. Bourne 1019
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