1974: Tumor Viruses, Vol. XXXIX
Organizer: James Watson
PART 1 Symposium Participants vForeword xviiOpening RemarksOncogenic Viruses: The Last Twelve Years R. Dulbecco 1SV40 AND POLYOMAGenome Structure and GeneticsAltered Patterns of Protein Synthesis in Infection by SV40 Mutants P. Tegt meyer 9The Semiautonomous Replicon: A Molecular Model for the Oncogenicity of SV40 R. G. Martin, J. Y. Chou, J. Avila and R. Saral 17Transformation of Primate and Rodent Cells by Temperature-sensitive Mutants of SV40 J. S. Butel, J. S. Brugge and C. A. Noonan 25Properties of Temperature-sensitive Mutants of Polyoma Virus W. Eckhart 37Indirect Complementation of a Nontransforming Mutant of Polyoma Virus T. L. Benjamin and E. Goldman 41Polyoma Virus - A Study of Wild-type, Mutant and Defective DNAs M. Fried, B. E. Griffin, E. Lund and D. L. Robberson 45Mapping the Genes of Simian Virus 40 C..J. Lai and D. Nathans 53Mapping of Mutational Alterations in DNA with Si Nuclease: The Location of Deletions, Insertions and Temperature-sensitive Mutations in SV40 T. E. Shenk, C. Rhodes, P. W. J. Rigby and P. Berg 61Isolation and Characterization of Individual Clones of Simian Virus 40 Mutants Containing Deletions, Duplications and Insertions in Their DNA J. E. Mertz, J. Carbon, M. Herzberg, R. W. Davis and P. Berg 69Characterization of Defective Simian Virus 40 DNA: Comparison between Large- plaque and Small-plaque Types K. Yoshiike, A. Furuno, S. Watanabe, S. Uchida, K. Matsubara and Y. Takagi 85Characterization of SV40 DNA Rescued from Transformed Mouse Cells M. Botchan, B. Ozanne and J. Sambrook 95Host Substitution in SV40 and Polyoma DNA E. Winocour, N. Frenkel, S. Lavi, M. Osenholts and S. Rozenblatt 101Electron Microscopic Mapping of the Attachment Sites on SV40 DNA during Lytic Infection L. T. Chow, H. W. Boyer, E. G. Tischer and H. M. Goodman 109Characterization of Cloned Evolutionary Variants of Simian Virus 40 W. W. Brockman, T. N. H. Lee and D. Nathans 119Specific Reiteration of Viral DNA Sequences in Mammalian Cells M. A. Martin, G. Khoury and G. C. Fareed 129Formation of Reiterated Simian Virus 40 DNA D. Davoli and G. C. Fareed 137The Detection and Quantitation of SV40 Nucleic Acid Sequences Using Single-stranded SV40 DNA Probes G. Khoury, P. Howley, M. Brown and M. Martin 147RNA TranscriptionNucleotide Sequence about the 3¢ Terminus of SV40 DNA Transcripts and the Region Where DNA Synthesis Is Initiated R. Dhar, K. Subramanian, B. S. Zain, J. Pan and S. M. Weissman 153Mapping of SV40 mRNA Species on the Viral Genome R. A. Weinberg and J. E. Newbold 161Biogenesis and Characterization of SV40 and Polyoma RNAs in Productively Infected Cells Y. Aloni 165Approaches to the Sequence Determination of SV40 DNA W. Fiers, K. Danna, R. Rogiers, A. Vandevoorde, J. Van Herreweghe, H. Van Heuverswyn, G. Volckaert and R. Yang 179Virus-specific RNA in Cells Productively Infected or Transformed by Polyoma Virus R. Kamen, D. M. Lindstrom, H. Shure and R. W. Old 187ReplicationStepwise Relaxation of Supercoiled SV40 DNA W. Keller and I. Wendel 199Properties of Replicating SV40 DNA Molecules and Mapping Unpaired Regions in SV40 DNA I N. P. Salzman, J. Lebowitz, M. Chen, E. Sebring and C. F. Garon 209Polyoma DNA Replication: Location of the Origin in Different Virus Strains L. V. Crawford, A. K. Robbins, P. M. Nicklin and K. Osborn 219Replication of Polyoma DNA: Effects of Hydroxyurea and Arabinosyl Cytosine G. Magnusson, R. Craig, M. Närkhammar, P. Reichard, M. Staub and H. War- ner 227Proteins and Their SynthesisFingerprints of Polyoma Virus Proteins and Mouse Histones G. Fey and B. Hirt 235Virion Proteins of Polyoma Temperature-sensitive Mutants: Late Mutants T. Friedmann and W. Eckhart 243Endonucleolytic Cleavage of Polyoma Virus DNA: General Properties and Site Specificity of the Virion-associated Endonuclease A. Parodi, P. Rouget, O. Croissant, D. Blangy and F. Cuzin 247Intermolecular Disulfide Bonds: An Important Structural Feature of the Polyoma Virus Capsid G. Walter and W. Deppert 255The Organization of Proteins in Polyoma and Cellular Chromatin A. J. Louie 259SV40: T Antigen, the A Function and Transformation M. Osborn and K. Weber 267Regulation of 5V40 Tumor Antigen in Transformed Mouse 3T3 Cells J. A. Robb 277SV40 T Antigen: Partial Purification and Properties D. M. Livingston, I. C. Henderson and J. Hudson 283Dissociation and DNA Binding of SV40 T Antigen R. B. Carroll, L. Hager and R. Dulbecco 291An Antigen Associated with Messenger RNA in a Transformed Hamster Cell Line M.-E. Mirault, S. I. Reed and G. R.Stark 295Cytosine Arabinoside- and Interferon-mediated Control of Polyoma and SV40 Genome Expression G. Brandner and N. Mueller 305The Cell-free Translation of SV40 Messenger RNA C. L. Prives, H. Aviv, E. Gil- boa, M. Revel and E. Winocour 309Transformed CellsThe Stable Classes of Transformed Cells Induced by SV40 Infection of Esta- blished 3T3 Cells and Primary Rat Embryonic Cells R. Risser, D. Ri/kin and R. Pollack 317Factors Affecting the Process and Extent of Integration of the Viral Genome K. Hirai and V. Defendi 325Genetics of Cell Transformation by Simian Virus 40 C. M. Croce, K. Huebner, A. J. Girardi and H. Koprowski 335Variants of Simian Virus 40-transformed Mouse Cells Resistant to Cytochalasin B F. Kelly and J. Sambrook 345The SV40 Rescue Problem J. F. Watkins 355Localization and Distribution of Actin Fibers in Normal, Transformed and Re- vertant Cells K. Weber, E. Lazarides, R. D. Goldman, A. Vogel and R. Pol- lack 363Differential Susceptibility to Amphotericin B of 3T3 Cells Transformed by SV40 or Polyoma P. Amati and C. Lago 371Infection of Mouse Blastocysts with SV40 DNA: Normal Development of the In- fected Embryos and Persistence of SV40-specific DNA Sequences in the Adult Animals R. Jacnisch 375A Simplifying Concept in Tumor Virology: Virus-specific "Pleiotropic Effectors" R. Weil, C. Salomon, E. May and P. May 381ADENO VIRUSESGenome Structure and GeneticsCleavage Maps of DNA from Adenovirus Types 2 and 5 by Restriction Endo- nucleases EcoRI and HpaI C. Mulder, J. R. Arrand, H. Delius, W. Keller, U. Pettersson, R. J. Roberts and P. A. Sharp 397Extent of Terminal Repetition in Adenovirus 2 DNA J. R. Arrand, W. Keller and R. J. Roberts 401Structural Studies on Two Adenovirus 2-SV40 Hybrids Which Contain the En- tire 5V40 Genome T. J. Kelly, Jr., A. M. Lewis, Jr., A. S. Levine and S. Siegel 409Cell Transformation: A Study of Regulation with Types S and 12 Adenovirus Temperature-sensitive Mutants H. S. Ginsberg, M. J. Ensinger, R. S. Kauff- man, A. J. Mayer and U. Lundholm 419Genetic Analysis of Human Adenovirus Type 5 in Permissive and Nonpermissive Cells J. F. Williams, C. S. H. Young and P. E. Austin 427Physical Mapping of Temperature-sensitive Mutations of Adenoviruses T. Grodzicker, J. Williams, P. Sharp and J. Sambrook 439TranscriptionRNA Synthesis and Processing in Adenovirus-infected Cells L. Philipson, U. Pettersson, U. Lind berg, C. Tibbetts, B. Vennstrom and T. Persson 447Mapping of Adenovirus 2 RNA Sequences in Lytically Infected Cells and Trans- formed Cell Lines P. A. Sharp. P. H. Gallimore and S. J. Flint 457An Examination of the Nuclear RNA of Adenovirus-transformed Cells M. Gear- gieff S. Bachenheimer and J. E. Darnell 475RNA Transcription in Cultures Productively Infected with Adenovirus 2 E. A. Craig, J. Tal, T. Nishimoto, S. Zimmer, M. MeGrogan and H. J. Raskas 483The Transcriptional Role of Host DNA-dependent RNA Polymerases in Adeno- virus-infected KB Cells R. Weinmann, H. J. Raskas and R. G. Roeder 495In Vitro Transcription of Adenovirus 2 DNA byE. coli RNA Polymerase S. Sur- zycki, J. A. Surzycki, W. DeLorbe and G. N. Gussin 501ReplicationIntegration of Adenovirus DNA into the Cellular Genome W. Doer/ler, H. Bur- ger, J. Ortin, E. Fanning, D. T. Brown, M. Westphal, U. Winterhoff, B. Weiser and J. Schick 505A Circular DNA-Protein Complex from Adenoviruses and Its Possible Role in DNA Replication A. J. Robinson and A. J. D. Bellett 523The Viral DNA Replication Machinery of Adenovirus 12 H. Shimojo, K. Shiroki and K. Yamaguchi 533The Mechanism of Replication of Adenovirus Type 5 DNA J. S. Sussenbach, D. J. Ellens, P. Ch. van der Vliet, M. G. Kuijk, P. H. Steenbergh, J. M. VIak, Th. H. RozUn and H. S. Jansz 539Origins and Termini of Adenovirus Type 2 DNA Replication E. L. Winnacker 547Proteins and Their SynthesisEarly Events in Adenovirus-infected Cells W. C. Russell 551Adenovirus-infected, Cell-specific, DNA-binding Proteins A. J. Levine, P. C. van der Vlict, B. Rosenwirth, J. Rabek, G. Frenkel and M. Ensinger 559Human Adenovirus Infection in Monkey Cells: An Example of Host Restriction at a Step Late in Replication S. G. Baum and R. I. Fox 567Analysis of Adenovirus Type 2 Gene Functions by Cell-free Translation of Viral Messenger RNA H. Westphal, L. Eron, F.-J. Ferdinand, R. Callahan and S-P. Lai 575The Origin and Destiny of Adenovirus Proteins J. B. Lewis, C. W. Anderson, J. F. Atkins and R. F. Gesteland 581Transformed CellsRecent Studies on the Characteristics of Adenovirus-infected and -transformed Cells J. K. McDougall, A. R. Dunn and P. H. Gallimore 591Properties and Behavior of Hamster Embryo Cells Transformed by Human Ad- enovirus Type 5 R. D. Goldman, C. Chang and J. F. Williams 601
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Viral DNA Sequences in Cells Transformed by Simian Virus 40, Adenovirus Type 2 and Adenovirus Type 5 J. Sambrook, M. Botchan, P. Gallimore, B. Ozanne, U. Pettersson, J. Williams and P. A. Sharp 615 Analysis of Multiple Viral Genome Fragments in Adenovirus 7-transformed Hamster Cells K. Fujinaga, K. Sekikawa, H. Yamazaki and M. Green 633 Studies on In Vitro Transformation by DNA and DNA Fragments of Human Adenoviruses and Simian Virus 40 F. L. Graham, P. J. Abrahams, C. Mul- der, H. L. He~neker, 5. 0. Warnaar, F. A. J. de Vries, W. Fiers and A. J. van der Eb 637 Studies of Hamster Cells Transformed by Adenovirus 2 and the Nondefective Ad2-SV40 Hybrids A. M. Lewis, Jr., J. H. Breeden, Y. L. Wewerka, L. E. Schnipper and A. S. Levine 651 PART 2 HERPES VIRUSES Herpes Simplex The Structure and Biological Properties of Herpes Simplex Virus DNA N. M. Wilkie, J. B. Clements, J. C. M. Macnab and J. H. Subak-Sharpe 657 Inverted Repetitions in the Chromosome of Herpes Simplex Virus P. Sheldrick and N. Berthelot- 667 Terminal Repetitions in Herpes Simplex Virus Type 1 DNA R. H. Grafstrom, J. C. Alwine, W. L. Steinhart and C. W. Hill 679 Analysis of DNA of Defective Herpes Simplex Virus Type 1 by Restriction Endo- nuclease Cleavage and Nucleic Acid Hybridization M. Wagner, J. Share and W. C. Summers 683 Regulation of Herpesvirus Macromolecular Synthesis: Evidence for Multilevel Regulation of Herpes Simplex 1 RNA and Protein Synthesis B. Roizman, M. Kozak, R. W. lioness and G. Hayward 687 Thymidine Kinase Isozymes of Normal and Virus-infected Cells S. Kit, W.-C. Leung, G. N. Jorgensen, D. Trkula and D. R. Dubbs 703 Genetic and Biochemical Studies with Herpesvirus J. H. Subak-Sharpe, S. M. Brown, D. A. Ritchie, M. C. Timbu,y, J. C. M. Macnab, H. S. Marsden and J. Hay 717 Viral Gene Functions Expressed and Detected by Temperature-sensitive Mutants of Herpes Simplex Virus M. Benyesh-Melnick, P. A. Schaffer, R. J. Courtney, J. Esparza and S. Kimura 731 Demonstration of the Oncogenic Potential of Herpes Simplex Viruses and Human Cytomegalovirus F. Rapp and J.-L. H. Li 747 Transformation of Cells by Herpes Simplex Virus - Fact or Fantasy? B. R. Mc- Auslan, B. Gar/inkle, R. Adler, D. Devinney, R. Florkiewicz and J. E. Shaw 765 Epstein-Barr Virus Immortalizing and Nonimmortalizing Laboratory Strains of Epstein-Barr Virus G. Miller, J. Robinson and L. Heston 773 Studies on the Epstein-Barr Virus Genome and the EBV-determined Nuclear Antigen in Human Malignant Disease G. Klein 783 EBV DNA in Nonlymphoid Cells of Nasopharyngeal Carcinomas and in a Malig- nant Lymphoma Obtained after Inoculation of EBV into Cottontop Marmo- sets H. Wolf J. Werner and H. zur Hausen 791 The Epstein-Barr Virus and Malignancy: Molecular Evidence J. S. Pagano 797 Plasmid DNA as a Possible State of Epstein-Barr Virus Genomes in Nonproduc- tive Cells M. Nonoyama and A. Tanaka 807 Sequence of Epstein-Barr Virus Productive Cycle in Human Lymphoblastoid Cells B. Hampar, J. G. Derge, A. Tanaka and M. Nonoyama 811 Response of B and T Lymphocytes and Other Blood Leukocytes in Chickens with Marek's Disease L. N. Payne, P. C. Powell and M. Rennie 817 Organization of Virion RNA Genome and Genetics Electron Microscope Studies of Tumor Virus RNA H. J. Kung, J. M. Bailey, N. Davidson, P. K. Vogt, M.O. Nicolson and R. M. McAllister 827 Electron Microscope Measurements of Rous Sarcoma Virus RNA H. Delius, P. H. Duesberg and W. F. Mangel 835 Determination of the Molecular Weight of the RNA Subunits of Rous Sarcoma Virus by Electron Microscopy A. B. Jacobson and P. A. Bromley 845 Avian RNA Tumor Viruses: Mechanism of Recombination and Complexity of the Genome P. Duesberg, P. K. Vogt, K. Beemon and M. Lai 847 35S a and b RNA Subunits of Avian RNA Tumor Virus Strains Cloned and Pas- saged in Chick and Duck Cells M. P. Stone, R. E. Smith and W. K. ,Joklik 859 Base Sequence Complexity of 35S Avian Myeloblastosis Virus RNA Determined by Molecular Hybridization Kinetics M. A. Baluda, M. Shoyab, P. D. Mark- ham, R. M. Evans and W. N. Drohan 869 Studies of the Interrelationship of Chicken Leukosis Virus and Host Cell Genomes by RNA-DNA Hybridization P. E. Neiman, S. E. Wright and H. G. Purchase 875 A Biochemical and Genetic Analysis of Mammalian RNA-containing Sarcoma Viruses E. M. Scolnick, R. J. Goldberg and W. P. Parks 885 Genetic Recombination among Temperature-sensitive Mutants of Rous Sarcoma Virus J. A. Wyke, J. G. Bell and J. A. Beamand 897 Phenotypically Mixed Vesicular Stomatitis Virus Particles Produced in Human Tumor Cell Lines J. Zavada, J. Bubenik, R. Widmaicr and Z. Zavadova 907 Phenotypic Mixing between Vesicular Stomatitis Virus and Avian RNA Tumor Viruses R. A. Weiss, D. Boettiger and D. N. Love 913 Reverse Transcriptase Role of the Subunits of the Avian RNA Tumor Virus Reverse Transcriptase A. Panet, I. M. Verma and D. Baltimore 919 Structure and Properties of an RNA Primer for Initiation of Rous Sarcoma Virus DNA Synthesis In Vitro J. E. Dahlberg, F. Harada and R. C. Sawyer 925 Relationships between Components in Primate RNA Tumor Viruses and in the Cytoplasm of Human Leukemic Cells: Implications to Leukemogenesis R. C. Gallo, R. E. Gallagher, N. R. Miller, H. Mondal, W. C. Saxinger, R. J. Mayer, R. G. Smith and D. H. Gillespie 933 Reverse Transcriptase Associated with A-type Particles from Murine Myeloma Cells R. E. Thach, D. L. Robertson, N. L. Baenziger and D. C. Dobbertin 963 Reverse Transcriptase and RNase H: Present in a Murine Virus and in Both Sub- units of an Avian Virus K. Moelling 969 Proviral DNA and Its Transcription Properties of Oncornavirus RNA-directed DNA Polymerase, the RNA Template, and the Intracellular Products Formed Early during Infection and Cell Transformation M. Green, D. Grandgenett, G. Gerard, H. M. Rho, M. C. Loni, M. Robins, S. Salzberg, G. Shanmugam, S. Bhaduri and G. Vecchio 975 Synthesis, Structure and Function of Avian Sarcoma Virus-specific DNA in Permissive and Nonpermissive Cells H. E. Varmus, R. V. Guntaka, C. T. Deng and J. M. Bishop 987 The Genome of RNA Tumor Viruses: A Functional Requirement for a Polyploid Structure? P. D. Cooper and J. A. Wyke 997 Studies on Characterization of the Integration Sites of Avian RNA Tumor Virus- specific DNA R. M. Evans, M. Shoyab and M. A. Baluda 1005 DNA-RNA Hybrid in Cells Infected by Murme Leukemia Virus T. Takano and M. Hatanaka 1009 Infectious Viral DNA in Rous Sarcoma Virus-transformed Nonproducer and Producer Animal Cells M. Hill, J. Hillova, D. Dantchev, R. Manage and G. Goubin 1015 Infectious DNA from Cells Infected with Rous Sarcoma Virus, Reticulcendothe- liosis Virus or Rous-associated Virus-0 G. M. Cooper and H. M. Temin 1027 AMV RNA Transcription in Cell-free Systems and Properties of In Vitro Chro- matin-directed RNA Synthesis G. Monroy, M. Jacquet, Y. Groner and J. Hurwitz 1033 Studies on the Structure and Synthesis of Rous Sarcoma Virus RNA C. Weiss- mann, J. T. Parsons, J. W. Coffin, L. Rymo, M. A. Billeter and H. Hofstetter 1043 Proteins Characterization of Murine Leukemia Virus-specific Proteins E. Fleissner, H. Ikeda, J-S. Tung, E. S. Vitetta, E. Tress, W. Hardy, Jr., E. Stockert, E. A. Boyse, T. Pincus and P. O'Donnell 1057 Synthesis of Avian RNA Tumor Virus Structural Proteins R. Eisenman, V. M. Vogt and H. Diggelmann 1067 Expression of Endogeneous Viruses Problems of RSV Rescue from Virogenic Mammalian Cells J. Svododa, I. Hlo žánek, O. Mach and S. Zadražil 1077 Qualitative and Quantitative Studies of AKR-type Murine Leukemia Virus Sequences in Mouse DNA S. K. Chattopadhyay, D. R. Lowy, N. M. Teich, A. S. Levine and W. P. Rowe 1085 Mechanism of Induction of RNA Tumor Viruses by Halogenated Pyrimidines P. Besmer, D. Smotkin, W. Haseltine, H. Fan, A. T. Wilson, M. Paskind, R. Weinberg and D. Baltimore 1103 Structural Proteins of RNA Tumor Viruses as Probes for Viral Gene Expression M. Strand and J. T. August 1109 Gen etic Control of the Expression of Murine Leukemia Virus Proteins in Tissues of Normal, Young Adult Mice M. Strand, F. Lilly and J. T. August 1117 Immune Response in the Mouse to Endogenous Leukemia Viruses R. C. Nowin- ski, S. L. Kaehler and R. R. Burgess 1123 Differential Cellular Regulation of Three Distinct Classes of Type C RNA Viruses Endogenous to Mouse Cells S. A. Aaronson and J. R. Stephenson 1129 Control of Expression of Tumor Virus Genes in Uninfected Chicken Cells H. Hanaf~tsa, W. S. Hayward, J. H. Chen and T. Hanafusa 1139 Endogenous Mammary Tumor Viruses in Mice P. Bentvelzen 1145 Glucocorticoid Induction of Murine Mammary Tumor Virus In Vitro W. P. Parks, E. M. Scolnick and J. C. Ransom 1151 Endogenous Primate and Feline Type C Viruses G. J. Todaro, R. E. Benveniste, R. Callahan, M. M. Lieber and C. J. Sherr 1159 Activation and Repression of Virus Expression in Mammalian Cells Infected by Rous Sarcoma Virus D. Boettiger 1169 Transformed Tumor Cell Surfaces The Chick Fibroblast Cell Surface after Transformation by Rous Sarcoma Virus P. W. Robbins, G. G. Wickus, P. E. Branton, B. J. Gaffney, C. B. Hirschberg, P. Fuchs and P. M. Blumberg 1173 The Role of Cell Surface Changes in RNA Tumor Virus-transformed Cells H. Bauer, R. Kurth, L. Rohrschneider, G. Pauli, R. R. Friis and H. Gelderblom 1181 Summary Tumor Viruses: 1974 D. Baltimore 1187
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