1971: Structure and Function of Proteins at the Three-Dimensional Level, Vol. XXXVI
Organizer: James Watson
Dedication vii Symposium Participants xiiiForeword xixGENERAL CONSIDERATION OF PROTEIN STRUCTURE AND CATALYSISStructure-Reactivity Correlations and General Acid-Base Catalysis in Enzymic Transacylation Reactions W. P. Jencks 1The Importance of Orientation Factors in Enzymatic Reactions D. E. Kosh land, Jr., K. W. Carraway, G. A. Dafforn, J. D. Gass, and D. R. Storm 13Views on Approximation, Orbital Steering, and Enzymatic and Model Reactions T. C. Bruice 21The Role of Distortion in the Lysozyme Mechanism B. D. Sykes, S. L. Patt, and D. Dolphin 29Protein Structure, Ribonuclease-S and Nucleotide Interactions F. M. Richards, H. W. Wyckoff, W. D. Carlson, N. M. Allewell, B. Lee, and Y. Mitsui 35Enzymatic Catalysis and the Transition State Theory of Reaction Rates: Transition State Analogs C. E. Lienhard, I. I. Secemski, K. A. Koehler, and R. N. Lindquist 45The Entatic State R. J. P. Williams 53PROTEASES: STRUCTURE, CATALYSIS, INHIBITIONa-Chymotrypsin: What Can We Learn about Catalysis from X-Ray Diffraction?R. Henderson, C. S. Wright, C. P. Hess, and D. M. Blow 63 Conformational Equilibria and the Salt Bridge in Chymotrypsin A. R. Fersht 71 Spectrophotometric and Structural Evidence as to the Mechanism of ProteaseCatalysis at Chemical Bonding Resolution S. A. Bernhard and S.-J. Lau 75 The Stereochemistry of Substrate Binding to Chymotrypsin Ag D. M. Segal,G. H. Cohen, D. R. Davies, J. C. Powers, and P. E. Wilcox 85 Conformational Changes and Inhibitor Binding at the Active Site of ElastaseD. M. Shotton, N. J. White, and H. C. Watson 91 A Comparison of the Three-dimensional Structures of Subtilisin BPN¢ and Subtilisin Novo J. Drenth, W. C. J. Hol, J. N. Jansonius, and R. Koekoek 107The Aromatic Substrate Binding Site in Subtilisin BPN¢ and Its Resemblance to Chymotrypsin J. Kraut, J. D. Robertus, J. J. Birktoft, R. A. Alden, P. E. Wilcox, and J. C. Powers 117The Crystal and Molecular Structure of DIP-inhibited Bovine Trypsin at 2.7 A Resolution R. M. Stroud, L. M. Kay, and R. E. Dickerson 125Pancreatic Trypsin Inhibitor (Kunitz) Part I. Structure and Function R Huber, D. Kukla, A. Ruhlmann, and W. Steigemann 141 Part II. Complexes with Proteinases A. Riihlmann, H. J. Schramm, D.Kukla, and R. Huber 148 ENZYMES IN THE GLYCOLYTIC PATHWAYCrystallographic Studies of Chicken Triose Phosphate Isomerase D. W. Banner, A. C. Bloomer, G. A. Petsko, D. C. Phillips and C. I. Pogson 151 Triosephosphate Isomerase: Isotope Studies on the Mechanistic Pathway J. R.. Knowles, P. F. Leadlay, and S. G. Maiste 157 X-Ray Diffraction Studies on Enzymes in the Glycolytic Pathway J. W. Campbell, E. Duee,G.. Hodgson, W. D. Mercer, D. K. Stammers, P. L. Wendell, H. Muirhead, and H. C. Watson 165 DEHYDROGENASESStructural Studies on Heart Muscle Malate Dehydrogenases D. Tsernoglou, E. Hill, and L. J. Banaszak 171 Structural Constraints on Possible Mechanisms of Lactate Dehydrogenase as Shown by High Resolution Studies of the Apoenzyme and a Variety of Enzyme Complexes M. G. Rossmann, M. J. Adams, M. Buehner, G. C. Ford, M. L. Hackert, P. J. Lentz, Jr., A. McPherson, Jr., R. W. Schevitz, and I. E. Smiley 179Relaxation Studies on an Allosteric Enzyme: Aspartokinase I-Homoserine Dehydrogenase I J. Janin 193A Low Resolution Electron-Density Map of Lipoyl Transsuccinylase, the Core of the a-Ketoglutarate Dehydrogenase Complex D. J. DeRosier and R. M. Olive 199MUSCLE PROTEINSTropomyosin Crystal Dynamics C. Cohen, D. L. D. Caspar, D. A. D. Parry, and R. M. Lucas 205The Structure of a Calcium-binding Protein from Carp Muscle R. H. Kretsinger, C. E. Nockolds, C. J. Coffee, and R. A. Bradshaw 217NEW PROTEIN STRUCTURES AND PROGRESS REPORTSCrystal Structure of Human Erythrocyte Carbonic Anhydrase C. VI. The Three- dimensional Structure at High Resolution in Relation to Other Mammalian Carbonic Anhydrases K. K. Kannan, A. Liljas, I. Waara, P.-C. Bergstén, S. Lbögren, B. Strandberg, U. Bengtsson, U. Carlbom, K. Fridborg, L. Järup,and M. Petef 221 The Crystal Structure of Rhombohedral 2 Zinc Insulin T. L. Blundell, J. F. Cutfield, B. J. Dodson, G. G. Dodson, D. C. Hodgkin, and D. A. Mercola 233Some Aspects of the Structure of Staphylococcal Nuclease. Part I. Crystallographic Studies F. A. Cotton, C. J. Bier, V. W. Day, B. B. Hazen, Jr., and S. Larsen 243 Part II. Studies in Solution C. B. Anfinsen, A. N. Schechter, and H. Taniuchi 249 Tentative Sequential Model for the Unfolding and Refolding of Staphylococcal Nuclease at High pH 0. Jardetzky, J. L. Markley, H. Thielmann, Y. Arata, and M. N. Williams 257Concerning the Stereochemistry of Actinomycin Binding to DNA: An Actino- mycin-Deoxyguanosine Crystalline Complex H. M. Sobell, S. C. Jam, T. D. Sakore, G. Ponticello, and C. E. Nordman 263X-Ray Crystallographic Studies of Concanavalin A K. D. Hardman, M. K. Wood, M. Schiffer, A. B. Edmundson, and C. F. Ainsworth 271The Structure of Concanavalin A at 4 A Resolution 0. N. Reeke, J. W. Becker, and F. A. Quiocho 277The 5.5 A Resolution Structure of the Regulatory Enzyme, Aspartate Trans- carbamylase D. C. Wiley, D. B. Evans, S. G. Warren, C. H. McMurray, B. F. P. Edwards, W. A. Franks, and W. N. Lipscomb 285Molecular Symmetry and Crystal Packing of E. coli Glutamine Synthetase D. Eisenberg, B. G. Heidner, P. Goodkin, M. N. Dastoor, B. H. Weber, F. Wedler, and J. D. Bell 291HEMOGLOBINS: MUTANTS, DERIVATIVES, AND COMPLEXESStereochemistry of Cooperative Effects in Hemoglobin M. F. Perutz and L. F. TenEyck 295The Effect of Removal of C-terminal Residues on Cooperative Interactions in Hemoglobin J. V. Kilmartin and J. A. Hewitt 311Three-dimensional Structure of Abnormal Mutant Human Hemoglobins J. Greer 315
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The Binding of a Spin-labeled Triphosphate to Hemoglobin R. T. Ogata and H. M. McConnell 325 An Allosteric Model of Hemoglobin R. G. Shulman, S. Ogawa, and J. J. Hopfield 337 Coboglobins: Cobalt Substitution and the Nature of the Prosthetic Group- Apoprotein Interaction in Hemoglobin and Myoglobin B. M. Hoffman, C. A. Spilburg, and D. H. Petering 343 The Structures of Lamprey and Bloodworm Hemoglobins in Relation to Their Evolution and Function W. B. Love, P. A. Klock, B. B. Lattman, B. A. Padlan, K. B. Ward, Jr., and W. A. Hendrickson 349 IRON-CONTAINING PROTEINS OTHER THAN HEMOGLOBIN The Structure of a Non-Heme Iron Protein: Rubredoxin at 1.5 A Resolution K. D. Watenpaugh, L. C. Sieker, J. B. Herriott, and L. H. Jensen 359 The Structure of a Clostridial Flavodoxin, an Electron-transferring Flavoprotein. III. An Interpretation of an Electron-Density Map at a Nominal Resolution of 3.25 A M. L. Ludwig, B. D. Andersen, P. A. Apgar, R. M. Burnett, M. E. LeQuesne, and S. G. Mayhew 369 Structure of the Iron-Sulfur Cluster in the Chromatium Iron Protein at 2.25 A Resolution C. W. Carter, Jr., S. T. Freer, Ng. H. Xuong, R. A. Alden, and J. Kraut 381 The Structure of Cytochrome b5 at 2.0 A Resolution F. S. Mathews, P. Argos, and M. Levine 387 Conformational Changes upon Reduction of Cytochrome c T. Takano, R. Swanson, 0. B. Kallai, and R. E. Dickerson 397 Pulsed NMR Study of the Structure of Cytochrome c A. G. Redfield and R. K. Gupta 405 IMMUNOGLOBIN STRUCTURE: IgG AND FRAGMENTS Crystal Structure of an Immunoglobulin Molecule by X-Ray Diffraction and Electron Microscopy V. R. Sarma, D. R. Davies, L. W. Labaw, E. W. Silverton and W. D. Terry 413 X-Ray Crystallographic Studies of the Fab and Fc Fragments of Human Myeloma Immunoglobulins R. J. Poljak, L. M. Amzel, H. P. Avey, L. N. Becka, D. J. Goldstein, and R. L. Humphrey 421 Crystallographic Studies of an IgG Immunoglobulin and the Bence-Jones Protein from One Patient A. B. Edmundson, M. Schiffer, M. K. Wood, K. D. Hard man, K. R. Ely, and C. F. Ainsworth 427 STRUCTURE OF VIRUSES An Electron-Density Map of Tobacco Mosaic Virus at 10 A Resolution A. N. Barrett, J. Barrington Leigh, K. C. Holmes, A. Klug, R. Leberman, E. Mandelkow, and P. Von Sengbusch 433 The Disk of TMV Protein and Its Relation to the Helical and Other Modes of Aggregation A. Klug and A. C. H. Durham 449 The Mechanism and Control of the Assembly of Tobacco Mosaic Virus from Its RNA and Protein Disks P. J. G. Butler 461 X-Ray Diffraction Studies of the Structure of Satellite Tobacco Necrosis Virus K. Akervall, B. St randberg, M. G. Rossmann, U. Bengtsson, K. Fridborg, H. Johannisen, K. K. Kannan, S. Lovgren, G. Petef, B. Öberg, D. Eaker, S. Hjertén, L. Ryden, and I. Moking 469 Three-dimensional Image Reconstructions of Some Small Spherical Viruses R. A. Crowther and L. A. Amos 489 Structure of Tomato Bushy Stunt Virus: Three-dimensional X-Ray Diffraction Analysis at 30 A Resolution S. C. Harrison 495 Structural Studies on the Adenovirus Hexon R. M. Franklin, S. C. Harrison, U. Pettersson, C.-I. Bräindén, P-E. Werner, and L. Philipson 503 SPECTROSCOPY AND SPECTROSCOPIC PROBES The Study of Biological Macromolecules Using Perturbed Angular Correlations of Gamma Radiation C. F. Meares and D. G. Westmoreland 511 Spectro-chemical Probes for Protein Conformation and Function B. L. Vallee,J. F. Riordan, J. T. Johansen, and D. M. Livingston 517 Mapping Active Sites of Phosphoryl-transferring Enzymes by MagneticResonance Methods M. Cohn, J. S. Leigh, Jr., and G. H. Reed 533 Use of 19F-Nuclear Magnetic Resonance Spectroscopy for Detection of ProteinConformation Changes: Application to Lysozyme, Ribonuclease, and Hemoglobin M. A. Raftery, W. H. Huestis, and F. Millet 541 On the Interpretation of Solvent Proton Magnetic Relaxation Data with Particular Application to the Structure of the Active Site of Mn-Carboxy- peptidase A S. H. Koenig, R. D. Brown, and J. Studebaker 551 X-Ray Diffraction and Nuclear Magnetic Resonance Dispersion Studies on Derivatives of Carboxypeptidase A F. A. Quiocho, P. H. Bethge, W. N. Lipscomb, J. F. Studebaker, R. D. Brown, and S. H. Koenig 561 TECHNIQUES IN DIFFRACTION AND MODEL BUILDING A Neutron Diffraction Analysis of Myoglobin. III. Hydrogen-Deuterium Bonding in Side Chains B. P. Schoenborn 569 The Use of a Computer-controlled Display System in the Study of Molecular Conformations C. D. Barry and A. C. T. North 577 Construction of Space-filling Models of Proteins Using Dihedral Angles J. A. Yankeelov, Jr., and J. B. Coggins 585 SUMMARY Protein Crystallography 1971: Coming of Age D. C. Phillips 589 Appendix: Stereo Plates 593 Subject Index 633 |
