1967: Antibodies, Vol. XXXII
Organizer: John Cairns
Foreword v List of Previous Volumes viPhotographs of Some Symposium Participants viiList of Those Attending the Symposium ixINTRODUCTIONSIR MACFARLANE BURNET. The Impact of Ideas on Immunology 1STRUCTURE OF ANTIBODIESPUTNAM, F. W., K. TITANI, M. WIKLER and T. SHINODA: Structure and evolution of kappa and lambda light chains 9MILSTEIN, C. B., B. FRANGIONI, and J. R. L. PINK: Studies on the variability of immunoglobulin sequence 31APPELLA, E. and R. M. PERHAM: Structure of immunoglobulin light chains 37PRESS, E. M. and P. J. PIGGOT: The chemical structure of the heavy chain of human immunoglobulin G 45WAXDAL, M. J., W. H. KONIGSBERG and G. M. EDELMAN: The structure of a human gamma G immunoglobulin 53CEBRA, J. J.: Common peptides comprising the N-terminal half of heavy chain from rabbit IgG and specific antibodies 65EISEN, H. N., J. R. LITTLE, C. K. OSTERLAND and E. S. SIMMS: A myeloma protein with antibody activity 75STONE, M. J. and H. METZGER: The valence of a Waldenstrom macroglobulin antibody and further thoughts on the significance of paraprotein antibodies 83NIZONOFF, A., S. ZAPPACOSTA and R. JUREZIZ: Properties of crystallized rabbit anti-P azobenzoate antibody 89POLJAK R. J., D. J. GOLDSTEIN, R. L. HUMPHREY and H. M. DINTZIS: Crystallo- graphic studies of rabbit and human Fc fragments 95SINGER, S. J., L. I. SLOBIN, N. O. THORPE and J. W. FENTON, II: On the structure of antibody active sites 99WOFSY, L. and D. C. PARKER: Comparative studies of antibody active sites 111YOO, T. J., O. A. ROHOLT, and D. PRESSMAN: Hapten binding activity in isolated light polypeptide chains from rabbit antibody 117KOSHLAND, M. E.: Location of specificity and allotypic amino acid residues in antibody Fd fragments 119HAMERS, R. and C. HAMERS-CASTERMAN: Evidence for the presence of the Fc allotypic marker As8 and the Fd allotypic marker Asi in the same molecules of rabbit IgG 129EVOLUTION AND GENETICS OF ANTIBODIESHOOD, L., W. R. GRAY, B. G. SANDERS and W. J. DREYER: Light chain evolution 133BAGLIONI, C., D. CIOLI, G. GORINI, A. RUFFILLI and L. ALESCIO-ZONTA: Studies on fragments of light chains of human immunoglobulins: Genetic and biochemical implications 147SMITHIES, O.: The genetic basis of antibody variability 161CRICK, F. H. C., L. HOOD, O. SMITHIES, W. J. DREYER, C. MILSTEIN, B. PAPERMASTER, N. A. MITCHISON, J. J. CEBRA, D. W. TALMAGE, C. BAGLIONI, G. EDELMAN, N. JERNE: General discussion on theories of antibody variability 169NATVIG, J. B., H. G. KUNKEL and S. P. LITWIN: Genetic markers of the heavy chain subgroups of human gamma G globulin 178 HERZENBERG, L. A., J. D. MINNA and L. A. HERZENBERG: The chromosome region for immunoglobulin heavy chains in the mouse: allelic electrophoretic mobility differences and allotype suppression 181POTTER, M. and R. LIEBERMAN: Genetic studies of immunoglobulins in mice 187MAGE, R. G.: Quantitative studies on the regulation of expression of genes for immunoglobulin allotypes in heterozygous rabbits 203SYNTHESIS OF ANTIBODIESCOHN, M.: Natural history of the mycloma 211ASKONAS, B. A. and A. R. WILLIAMSON: Biosynthesis and assembly of immuno- globulin G 223FLEISCHMAN, J. B.: Synthesis of the rabbit gamma G heavy chain 233SCHARFF, M. D., A. L. SHAPIRO and B. GINSBERG: The synthesis, assembly and secretion of gamma globulin polypeptide chains by cells of a mouse plasma cell tumor 235GREENBERG, L. J. and J. W. UHR: DNA-RNA hybridization studies of immuno- globulin synthesizing tumors in mice 243LENNOX, E. S., P. M. KNOPE, A. J. MUNRO and R. M. E. PARKHOUSE: A search for biosynthetic subunits of light and heavy chains of immunoglobulins 249MELCHERS, F. and P. M. KNOPF: Biosynthesis of the carbohydrate portion of immunoglobulin chains: Possible relation to secretions 255MOROZ, C. and J. W. UHR: Synthesis of the carbohydrate moiety of gamma globulin 263KERN, M. and R. M. SWENSON: Biochemical studies of the intracellular events involved in the secretion of gamma globulin 265MACH, B., H. KOBLET and D. GROSS: Biosynthesis of immunoglobulin in a cell- free system 269
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RALPH, P., M. BECKER and A. RICH: Immunoglobulin synthesis in a cell-free system 277 FAHEY, J. L. and I. FINEGOLD: Synthesis of immunoglobulins in human lymphoid cell lines 283 REISFELD, R. A.: Heterogeneity of rabbit light-poly peptide chains 291 HABER, E., F. F. RICHARDS, J. SPRAGG, K. F. AUSTEN, M. VALLOTTON and L. B. PAGE: Modifications in the heterogeneity of the antibody response 299 DUBISKI, S.: Synthesis of allotypically defined immunoglobulins in rabbits 311 CHOU, C. T., B. CINADER, and S. DUBISKI: Quantitative studies of antibody production by plaque-forming cells 317 PERNIS, B.: Relationships between the heterogeneity of immunoglobulins and the differentiation of plasma cells 333 FISHMAN, M. and F. L. ADLER: The role of macrophage-~RNA in the immune response 343 COHEN, E. P. and K. RASKA: Antigen-unique species of RNA in peritoneal cells of mice which do not adhere to glass 349 DREYER, W. J., W. R. GRAY, and L. HOOD: The genetic, molecular, and cellular basis of antibody formation: some facts and a unifying hypothesis 353 DIFFERENTIATION AND CELLULAR EVENTS NOSSAL, G. J. V., K. D. SHORTMAN, J. F. A. P. MILLER, G. F. MITCHELL, and J. S. HASKILL: The target cell in the induction of immunity and tolerance 369 ADA, G. L., C. R. PARRISH, G. J. V. NOSSAL, and A. ABBOT: The tissue localiz- ation, immunogenic, and tolerance-inducing properties of antigens and antigen-fragments 381 ELLIS, S. T., J. L. GOWANS and J. C. HOWARD: Cellular events during the formation of antibody 395 DUTTON, R. W. and R. I. MISHELL: Cellular events in the immune response. The in vitro response of normal spleen cells to erythrocyte antigens 407 FELDMAN, M. and R. GALLILY: Cell interactions in the induction of antibody formation 415 MÄKELÄ, O: The Specificities of antibodies produced by single cells 423 MITCHISON, N. A.: Antigen recognition responsible for the induction in vitro of the secondary response 431 GELL, P. G. H.: Restrictions on antibody production by single cells 441 PAPERMASTER, B. W.: The clonal differentiation of antibody-producing cells 447 TILL, J. E., E. A. MCCULLOCH, R. A. PHILLIPS and L. SIMINOVITCH: Analysis of differentiating clones derived from marrow 461 BUSSARD, A. E.: Primary antibody response induced in vitro among cells from normal animals 465 LITT, M.: Studies of the latent period. I. Primary antibody in guinea pig lymph nodes 7½ minutes after introduction of chicken erythrocytes 477 ŠTERZL, J.: Factors determining the differentiation pathways of immuno- competent cells 493 WIGZELL, T.: Studies on the regulation of antibody synthesis 507 SIMONSEN, M.: The clonal selection hypothesis evaluated by grafted cells reacting against their hosts 517 FAZEKAS, S. de ST. GROTH: Cross recognition and cross reactivity 525 SELA, M., B. SCHECHTER, I. SCHECHTER, and F. BOREK: Antibodies to sequential and conformational determinants 537 RAJEWSKY, K. and E. ROTTLANDER: Tolerance specificity and the immune response to lactic dehydrogenase isoenzymes 547 WEIGLE, W. O. and E. S. GOLUB: Kinetics of the establishment of immunological unresponsiveness to serum protein antigens 555 HAUROWITZ, F.: Evolution of selective and instructive theories of antibody formation 559 BENACERRAF, B., I. GREEN, and W. E. PAUL: The immune response of guinea pigs to hapten-poly-L-lysine conjugates as an example of the genetic control of the recognition of antigenicity 569 SJÖQUIST, J., A. FORSGREN, G. T. GUSTAFSON, and G. STÅLENHEIM: Biological importance of the Fc-region of gamma globulins 577 METCALF, D.: Relation of the thymus to the formation of the immunologically reactive cells 583 SUMMARY JERNE, N. K.: Waiting for the End 591
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